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Discussion on the indication of allogeneic stem cell transplantation for advanced cutaneous T cell lymphomas

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Abstract

Advanced cutaneous T cell lymphoma (CTCL) patients have a dismal prognosis, especially those relapsing or progressing after systemic therapy. No curative therapies are available, but some new agents have prolonged disease-free survival time with a good toxicity profile. Allogeneic stem cell transplantation (allo-SCT) offers the longest disease-free survival, potentially representing the best therapeutic option for eligible patients. In the present article, we discuss current evidence about allo-SCT for CTCL patients, timing, and new therapeutic options before allo-SCT, taking into account some considerations that may impact clinical outcome.

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Acknowledgements

This work was supported in part by Grant 2017 SGR 1395 from the Catalan Government, Grant from “Obra Social La Caixa” Barcelona Spain, and grant Tercel RD16/0011/0028 from the Instituto de Salud Carlos III, Ministerio de Economía y Competitividad, Spain.

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Author notes

  1. Javier Briones and Jorge Sierra are senior authors of this work.

Authors and Affiliations

  1. Hematology Department, Hospital de la Santa Creu i Sant Pau, José Carreras Leukemia Research Institute and IIB Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain

    Silvana Novelli, Anna Monter, Rodrigo Martino, Javier Briones & Jorge Sierra

  2. Dermatology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain

    M. Pilar García-Muret

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  1. Silvana Novelli
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  2. Anna Monter
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  3. M. Pilar García-Muret
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  4. Rodrigo Martino
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Correspondence to Silvana Novelli.

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Novelli, S., Monter, A., Pilar García-Muret, M. et al. Discussion on the indication of allogeneic stem cell transplantation for advanced cutaneous T cell lymphomas. Int J Hematol 110, 406–410 (2019). https://doi.org/10.1007/s12185-019-02707-w

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  • DOI: https://doi.org/10.1007/s12185-019-02707-w

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