ARID5B gene polymorphisms and the risk of childhood acute lymphoblastic leukemia: a meta-analysis
Genome-wide association studies have implicated several single-nucleotide polymorphisms (SNPs) in the AT-rich interactive domain 5B (ARID5B) gene in children with ALL; however, whether ARID5B variants (rs10821936, rs10994982, rs7089424) are associated with childhood ALL remains controversial. We performed this study to obtain more conclusive results. Eligible studies were searched in PubMed, Web of Science, and EMBASE. Odds ratios and 95% confidence intervals were calculated. A total of 26 studies were included. Analyses stratified by ethnicity revealed that three polymorphisms are significantly associated with the odds of childhood ALL in Caucasians, and rs10994982 and rs7089424 with the odds of childhood ALL in Asian populations. Furthermore, subtype analyses provided strong evidence that the three polymorphisms are highly associated with the risk of B-cell ALL. Our findings indicate that the ARID5B variants (rs10821936, rs10994982, rs7089424) are significantly associated with the risk of childhood ALL.
KeywordsARID5B Childhood leukemia Meta-analysis
Genome-wide association studies
AT-rich interactive domain 5B
Acute lymphoblastic leukemia
The author contributions were as follows: JY collected, performed the statistical analysis and interpreted the data, drafted and revised the manuscript. YL collected and interpreted the data and revised the manuscript. HW and YB supervised the analysis and interpretation of data, and reviewed the manuscript. All authors contributed to the discussion of the results. All authors read and approved the final version of the manuscript.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
- 5.Imai K. Acute lymphoblastic leukemia: pathophysiology and current therapy. Rinsho Ketsueki. 2017;58(5):460–70.Google Scholar
- 9.Wilsker D, Patsialou A, Dallas PB, Moran E. ARID proteins: a diverse family of DNA binding proteins implicated in the control of cell growth, differentiation, and development. Cell Growth Differ. 2002;13(3):95–106.Google Scholar
- 13.Kreile M, Rots D, Zarina A, Rautiainen L, Visnevska-Preciniece Z, Kovalova Z, et al. Association of ARID5B genetic variants with risk of childhood B cell precursor acute lymphoblastic leukaemia in Latvia. Asian Pac J Cancer Prev. 2018;19(1):91–5.Google Scholar
- 17.Bhandari P, Ahmad F, Mandava S, Das BR. Association of genetic variants in ARID5B, IKZF1 and CEBPE with risk of childhood de novo B-lineage acute lymphoblastic leukemia in India. Asian Pac J Cancer Prev. 2016;17(8):3989–95.Google Scholar
- 18.Bekker-Mendez VC, Nunez-Enriquez JC, Torres Escalante JL, Alvarez-Olmos E, Gonzalez-Montalvoc PM, Jimenez-Hernandez E, et al. ARID5B, CEBPE and PIP4K2A germline genetic polymorphisms and risk of childhood acute lymphoblastic leukemia in Mexican patients: a MIGICCL study. Arch Med Res. 2016;47(8):623–8.CrossRefGoogle Scholar
- 28.Gharbi H, Ben Hassine I, Soltani I, Safra I, Ouerhani S, Bel Haj Othmen H, et al. Association of genetic variation in IKZF1, ARID5B, CDKN2A, and CEBPE with the risk of acute lymphoblastic leukemia in Tunisian children and their contribution to racial differences in leukemia incidence. Pediatr Hematol Oncol. 2016;33(3):157–67.CrossRefGoogle Scholar
- 29.Hsu LI, Chokkalingam AP, Briggs FB, Walsh K, Crouse V, Fu C, et al. Association of genetic variation in IKZF1, ARID5B, and CEBPE and surrogates for early-life infections with the risk of acute lymphoblastic leukemia in Hispanic children. Cancer Causes Control. 2015;26(4):609–19.CrossRefGoogle Scholar