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Brentuximab vedotin as frontline treatment for HIV-related extracavitary primary effusion lymphoma

  • Jose D. Sandoval-SusEmail author
  • Amanda Brahim
  • Alina Khan
  • Barbara Raphael
  • Ali Ansari-Lari
  • Marco Ruiz
Case Report
  • 62 Downloads

Abstract

Primary effusion lymphoma (PEL) is a rare and aggressive herpesvirus-8 (HHV-8) driven B cell non-Hodgkin’s lymphoma (NHL) that is usually associated with human immunodeficiency virus (HIV) infection, and has a poor prognosis. PEL is comprised of two clinically distinct but pathologically similar variants: classic and extracavitary PEL. Based on retrospective series, treatment options include combined antiretroviral therapy (cART) in conjunction with chemotherapy regimens used in other forms of NHLs. Treatment outcomes with this approach are usually dismal and there is no standard of care. We present a case of a patient with HIV associated CD30+ extracavitary PEL unfit for multi-agent chemotherapy, who achieved a durable complete response with single agent brentuximab-vedotin and cART.

Keywords

Primary effusion lymphoma Human immunodeficiency virus AIDS 

Notes

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Copyright information

© Japanese Society of Hematology 2019

Authors and Affiliations

  1. 1.Department of Malignant Hematology and Cellular Therapy at Memorial Healthcare SystemH. Lee Moffitt Cancer CenterPembroke PinesUSA
  2. 2.Department of PharmacyMemorial Healthcare SystemPembroke PinesUSA
  3. 3.Department of Diagnostic RadiologyMemorial Healthcare SystemPembroke PinesUSA
  4. 4.Division of Hematopathology, Department of Anatomic and Clinical PathologyMemorial Healthcare SystemHollywoodUSA

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