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International Journal of Hematology

, Volume 108, Issue 2, pp 233–235 | Cite as

Correction to: Effects of eculizumab treatment on quality of life in patients with paroxysmal nocturnal hemoglobinuria in Japan

  • Yasutaka Ueda
  • Naoshi Obara
  • Yuji Yonemura
  • Hideyoshi Noji
  • Masayoshi Masuko
  • Yoshinobu Seki
  • Katsuya Wada
  • Takahisa Matsuda
  • Hirozumi Akiyama
  • Takayuki Ikezoe
  • Shigeru Chiba
  • Yoshinobu Kanda
  • Tatsuya Kawaguchi
  • Tsutomu Shichishima
  • Hideki Nakakuma
  • Shinichiro Okamoto
  • Jun-ichi Nishimura
  • Yuzuru Kanakura
  • Haruhiko Ninomiya
Correction
  • 143 Downloads

Correction to: International Journal of Hematology (2018) 107:656–665  https://doi.org/10.1007/s12185-018-2409-3

In the original publication of this article, Tables 2, 3 and 4 were published incorrectly. The corrected Tables 2, 3 and 4 are given in the following pages.

Table 2

Disease characteristics at baseline

 

Post-marketing

QOL

BMF (+)

BMF (−)

LDH (U/L)

 n

477

51

30

21

 Mean (SD)

1478.3 (776.3)

1435.3 (922.6)

1161.8 (591.4)

1826.0 (1161.2)

 Median (min, max)

1340.0 (157, 6082)

1131.0 (447, 6082)

1049.0 (447, 2870)

1638.0 (618, 6082)

Hb (g/dL)

 n

480

52

31

21

 Mean (SD)

8.04 (1.70)

8.22 (1.92)

8.17 (2.19)

8.29 (1.47)

 Median (min, max)

7.90 (3.8, 15.0)

8.20 (4.5, 15.0)

8.20 (4.5, 15.0)

8.20 (5.7, 11.5)

PLT (× 103/µL)

 n

451

51

30

21

 Mean (SD)

133.3 (80.6)

129.1 (69.3)

103.0 (59.3)

166.4 (66.6)

 Median (min, max)

126.0 (4, 574)

128.0 (12, 281)

93.0 (12, 228)

172.0 (60, 281)

PNH clone size (%)

 n

241

26

14

12

 Mean (SD)

42.18 (23.90)

34.94 (26.66)

32.93 (29.62)

37.28 (23.81)

 Median (min, max)

40.00 (0.0, 99.0)

23.35 (1.7, 97.0)

19.20 (10.2, 97.0)

36.70 (1.7, 83.5)

PNH clone size (%) was evaluated by erythrocytes

Table 3

Changes in laboratory data from baseline to 1-year

 

Baseline

1 year

Paired t test

LDH (U/L) (n = 51)

 Mean (SD)

1435.3 (922.6)

292.2 (170.7)

P < 0.01

 Median (min, max)

1131.0 (447, 6082)

242.0 (148, 1045)

Hb (g/dL) (n = 52)

 Mean (SD)

8.22 (1.92)

9.37 (1.97)

P < 0.01

 Median (min, max)

8.20 (4.5, 15.0)

9.35 (5.1, 14.3)

PLT (× 103/µL) (n = 51)

 Mean (SD)

129.1 (69.3)

133.8 (64.8)

N.S.

 Median (min, max)

128.0 (12, 281)

137.0 (11, 306)

eGFR (mL/min/1.73 m2) (n = 29)

 Mean (SD)

73.75 (37.87)

75.57 (38.47)

N.S.

 Median (min, max)

58.60 (27.0, 161.3)

64.80 (25.2, 171.1)

PNH clone size (%) (n = 5)

 Mean (SD)

28.88 (30.81)

33.60 (16.41)

N.S.

 Median (min, max)

18.80 (11.0, 83.5)

23.50 (19.3, 52.0)

PNH clone size (%) was evaluated by erythrocytes

Table 4

Canonical correlation analysis between changes in laboratory data and changes in QOL scores

 

Canonical correlation coefficient

FACIT-fatigue

EORTC-QLQ-C30

0.74

 Global health status/QoL

0.69

 Physical functioning

0.72

 Role functioning

0.64

 Emotional functioning

0.38

 Cognitive functioning

0.20

 Social functioning

0.59

 Fatigue

− 0.87

 Nausea and vomiting

− 0.44

 Pain

− 0.27

 Dyspnea

− 0.70

 Insomnia

− 0.58

 Appetite loss

− 0.55

 Constipation

− 0.12

 Diarrhea

− 0.16

 Financial difficulties

− 0.51

Laboratory value

 

 LDH

− 0.91

 Hb

0.76

 PLT

0.03

Statistics

 Canonical R

0.8393

 F value

1.9166

 P value

0.0042

Copyright information

© The Japanese Society of Hematology 2018

Authors and Affiliations

  • Yasutaka Ueda
    • 1
    • 2
  • Naoshi Obara
    • 2
    • 3
  • Yuji Yonemura
    • 2
    • 4
  • Hideyoshi Noji
    • 2
    • 5
  • Masayoshi Masuko
    • 6
  • Yoshinobu Seki
    • 7
    • 8
  • Katsuya Wada
    • 9
  • Takahisa Matsuda
    • 10
  • Hirozumi Akiyama
    • 10
  • Takayuki Ikezoe
    • 2
    • 5
  • Shigeru Chiba
    • 2
    • 11
  • Yoshinobu Kanda
    • 2
    • 12
  • Tatsuya Kawaguchi
    • 2
    • 13
  • Tsutomu Shichishima
    • 2
    • 5
  • Hideki Nakakuma
    • 2
    • 14
  • Shinichiro Okamoto
    • 2
    • 15
  • Jun-ichi Nishimura
    • 1
    • 2
  • Yuzuru Kanakura
    • 1
    • 2
  • Haruhiko Ninomiya
    • 2
    • 16
  1. 1.Department of Hematology and OncologyOsaka University Graduate School of MedicineSuitaJapan
  2. 2.Japan PNH Study GroupTokyoJapan
  3. 3.Department of HematologyUniversity of TsukubaTsukubaJapan
  4. 4.Department of Transfusion Medicine and Cell TherapyKumamoto University HospitalKumamotoJapan
  5. 5.Department of HematologyFukushima Medical UniversityFukushimaJapan
  6. 6.Department of Stem Cell TransplantationNiigata University HospitalNiigataJapan
  7. 7.Department of HematologyNiigata Prefectural Shibata HospitalShibataJapan
  8. 8.Department of Hematology, Uonuma Institute of Community MedicineNiigata University Medical and Dental HospitalMinami-UonumaJapan
  9. 9.Department of HematologyMatsushita Memorial HospitalMoriguchiJapan
  10. 10.Alexion Pharma G.KTokyoJapan
  11. 11.Department of Hematology, Faculty of MedicineUniversity of TsukubaTsukubaJapan
  12. 12.Division of HematologyJichi Medical UniversityShimotsukeJapan
  13. 13.Departments of Hematology and Infectious DiseasesKumamoto UniversityKumamotoJapan
  14. 14.Kagoshima Tokusyukai HospitalKagoshimaJapan
  15. 15.Division of Hematology, Department of MedicineKeio University School of MedicineTokyoJapan
  16. 16.Department of Medical Sciences, Faculty of MedicineUniversity of TsukubaTsukubaJapan

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