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International Journal of Hematology

, Volume 108, Issue 5, pp 550–553 | Cite as

A unique clinical presentation of de novo acute promyelocytic leukemia as a myeloid sarcoma of the breast

  • Iveta Oravcova
  • Eva Mikuskova
  • Michaela Leitnerova
  • Jan Gyarfas
  • Andrea Mlcakova
  • Peter Szepe
  • Lukas Plank
  • Ludmila Demitrovicova
  • Vanda Mikudova
  • Silvia Cingelova
  • Michal Mego
  • Lubos Drgona
Case Report
  • 76 Downloads

Abstract

Myeloid sarcoma is a rare presentation of acute leukemia as a solid tumor at various extramedullary sites. It may present concurrently, before or after the onset of systemic bone marrow leukemia. Unusual clinical localization may lead to misdiagnosis, or delayed diagnosis and treatment. We describe the first case, to our knowledge, of de novo myeloid sarcoma of the breast confirmed as acute promyelocytic leukemia. Immunohistochemical analysis, flow cytometry, fluorescent in situ hybridization analysis and molecular analysis using RQ-PCR of tissue samples should be routine in determining the correct diagnosis in this setting.

Keywords

Acute leukemia Promyelocytic Myelosarcoma Diagnosis 

Notes

Acknowledgements

We thank to all nurses and medical staff involved in the treatment of the patient.

Compliance with ethical standards

Conflict of interest

On behalf of all the authors I declare that there are no competing financial interests in relation to the work described in the manuscript.

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Copyright information

© The Japanese Society of Hematology 2018

Authors and Affiliations

  • Iveta Oravcova
    • 1
    • 2
  • Eva Mikuskova
    • 1
  • Michaela Leitnerova
    • 3
  • Jan Gyarfas
    • 4
  • Andrea Mlcakova
    • 4
  • Peter Szepe
    • 5
  • Lukas Plank
    • 5
  • Ludmila Demitrovicova
    • 1
  • Vanda Mikudova
    • 1
  • Silvia Cingelova
    • 1
  • Michal Mego
    • 6
  • Lubos Drgona
    • 2
  1. 1.Department of Oncohematology IINational Cancer InstituteBratislavaSlovakia
  2. 2.Oncohematology Clinic, Faculty of MedicineComenius University and National Cancer InstituteBratislavaSlovakia
  3. 3.Department of Medical GeneticsNational Cancer InstituteBratislavaSlovakia
  4. 4.Department of Laboratory HematologyNational Cancer InstituteBratislavaSlovakia
  5. 5.Department of PathologyJessenius Faculty of Medicine, The Comenius UniversityMartinSlovakia
  6. 6.2nd Department of Oncology, Faculty of MedicineComenius University and National Cancer InstituteBratislavaSlovakia

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