The hematopoietic stem cell diet

Progress in Hematology The regulatory signal for normal and abnormal hematopoiesis


Hematopoietic stem cells (HSCs) are responsible for sustaining life-long blood formation or hematopoiesis and are also used clinically in a form of bone marrow transplantation, a curative cellular therapy for a range of hematological diseases. HSCs are maintained throughout adult life by a complex biological niche or microenvironment, which is thought to be composed of a range of cellular, molecular, and metabolic components. The metabolic components of the HSC niche have become of increasing interest over the past few years. It is now well-recognized that metabolic activity is intimately linked to HSC function, and dysregulation of these metabolic pathways result in hematological pathologies such as leukemia. Here, we review the recent progress in this field including our current understanding of the “dietary” requirements of HSCs and how nutrition influences HSC activity. These recent findings have suggested promising new metabolic approaches to improve clinical HSC transplantation and leukemia therapies.


Hematopoietic stem cell Metabolism Nutrition HSC Hematopoietic stem cell transplantation Leukemia 



We thank H. J. Beker and other members of the Yamazaki laboratory for feedback on the manuscript. We apologize to those authors whose work could not be cited due to space constraints. SY is supported by the Japan Society for the Promotion of Science (JSPS) (Grant no. 50625580), and the Ministry of Education, Culture, Sport, Science, and Technology (Japan). ACW is supported by Bloodwise (15050) and the NIH National Center for Advancing Translational Science Clinical and Translational Science Award (UL1 TR001085). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.


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Copyright information

© The Japanese Society of Hematology 2018

Authors and Affiliations

  1. 1.Institute for Stem Cell Biology and Regenerative MedicineStanford University School of MedicineStanfordUSA
  2. 2.Department of GeneticsStanford UniversityStanfordUSA
  3. 3.Division of Stem Cell Therapy, Institute of Medical ScienceUniversity of TokyoTokyoJapan

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