The significance and application of vascular niche in the development and maintenance of hematopoietic stem cells

Progress in Hematology The regulatory signal for normal and abnormal hematopoiesis
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Abstract

Deriving hematopoietic stem cells (HSCs) from human pluripotent stem cells is one of major goals in stem cell and hematological research. To induce HSCs from human pluripotent stem cells, many attempts to mimic embryonic development through stepwise exposure to morphogens. HSCs arise from dorsal aorta of embryos then migrate and settle in the bone marrow. Development and maintenance of HSCs are controlled by the microenvironmental cues around the blood vessels (called vascular niche) through morphogens and cytokines. Vascular niche serves as a common mechanism from embryo development to life-long maintenance of HSCs. In this chapter, I discuss that how vascular niche regulates development and maintenance of HSCs and exemplify the role of vascular niche to exquisitely induce HSCs from human pluripotent stem cells.

Keywords

Hematopoietic stem cell Pluripotent stem cell Niche Transcriptional regulation Signaling 

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Copyright information

© The Japanese Society of Hematology 2018

Authors and Affiliations

  1. 1.Stem Cell Transplantation Program, Division of Pediatric Hematology and OncologyDana-Farber Cancer Institute, Boston Children’s HospitalBostonUSA

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