International Journal of Hematology

, Volume 108, Issue 2, pp 161–166 | Cite as

Clinical characteristics and outcomes of diffuse large B-cell lymphoma in adolescents and young adults

  • Yasuhiro SuzukiEmail author
  • Takahiro Yano
  • Youko Suehiro
  • Hiromi Iwasaki
  • Michihiro Hidaka
  • Maki Otsuka
  • Kazutaka Sunami
  • Nobumasa Inoue
  • Morio Sawamura
  • Takuo Ito
  • Hiroatsu Iida
  • Hirokazu Nagai
Original Article


Clinical information regarding non-Hodgkin lymphoma (NHL) in adolescents and young adults (AYA) is lacking. We retrospectively analyzed 1426 consecutively registered patients with newly diagnosed NHL. Of 798 DLBCL patients, 42 (5.3%) were identified as AYA (16–39 years). The characteristics of AYA DLBCL patients showed no significant differences compared to older adult DLBCL patients (age ≥ 40 years). Progression-free survival (PFS) and overall survival (OS) in AYA were similar to those in patients aged 40–60 years. However, in older adult groups, PFS and OS were significantly different according to the age group (40–60, 61–79, and ≥ 80 years). In univariate analysis in AYA, performance status, clinical stage, International Prognostic Index (IPI), and age-adjusted IPI significantly affected both PFS and OS. In multivariate analysis, only clinical stage was identified as an independent predictor among AYA. In conclusion, disease characteristics and outcomes of DLBCL in AYA were nearly the same as those in older adults.


Non-Hodgkin lymphoma Diffuse large B-cell lymphoma Adolescents Young adults Clinical practice 



This work was supported by a Grant-in-Aid for Clinical Research from the National Hospital Organization. We thank all the participating centers and collaborators of Clinical Hematology Group of National Hospital Organization (CHG-NHO); NHO Hokkaido Medical center, NHO Mito Medical center, NHO Matsumoto Medical center, NHO Kanazawa Medical center, NHO Himeji Medical center, NHO Minami-Okayama Medical center, NHO Hiroshima-Nishi Medical center, and NHO Nagasaki Medical center, for the registration of patients.

Author contributions

HN designed the research; TY, YoS, HIw, MH, MO, KS, NI, MS, TI, and HIi provided the data and contributed to patient care; Ya.S. and HN analyzed and interpreted the data and wrote the manuscript; and all the authors reviewed and revised the manuscript.

Compliance with ethical standards


Hirokazu Nagai has received research funding from Janssen Pharmaceutical K. K., Mundipharma K.K., Celgene Corporation, Bayer Yakuhin Ltd., Abbvie G.K., Takeda Pharmaceutical Co., Ltd., Chugai Pharmaceutical Co., Ltd., Kyowa Hakko Kirin Co., Ltd., and Esai Co., Ltd., and honoraria from Chugai Pharmaceutical Co., Ltd., Mundipharma K.K., Esai Co., Ltd., Sanofi K.K., and Janssen Pharmaceutical K. K. Kazutaka Sunami has received research funding from MSD K. K., Celgene Corporation, and honoraria from Celgene Corporation, Ono Pharmaceutical Co., Ltd., Bristol-Myers Squibb. Morio Sawamura has received honoraria from Ono Pharmaceutical Co., Ltd. and Takeda Pharmaceutical Co., Ltd.

Supplementary material

12185_2018_2449_MOESM1_ESM.eps (670 kb)
Supplementary material 1 (EPS 669 kb) Supplemental Fig. 1. Progression-free survival and overall survival of AYA DLBCL patients, comparing the rituximab-containing regimen (rituximab group) with the non-rituximab-containing regimen (non-rituximab group). Kaplan–Meier analysis of progression-free survival (PFS) (a) and overall survival (OS) (b) of AYA DLBCL patients, comparing the rituximab-containing regimen (rituximab group) with the non-rituximab-containing regimen (non-rituximab group) is shown. In this study, the administration of rituximab did not significantly affect PFS and OS (PFS: p = 0.2837, OS: p = 0.4337)
12185_2018_2449_MOESM2_ESM.eps (868 kb)
Supplementary material 2 (EPS 868 kb) Supplemental Fig. 2. Progression-free survival and overall survival in all DLBCL patients, comparing the rituximab-containing regimen (rituximab group) with the non-rituximab-containing regimen (non-rituximab group). Kaplan–Meier analysis of progression-free survival (PFS) (a) and overall survival (OS) (b) in all DLBCL patients showed that the administration of rituximab significantly improved PFS and OS (both P < 0.0001)


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Copyright information

© The Japanese Society of Hematology 2018

Authors and Affiliations

  • Yasuhiro Suzuki
    • 1
    • 12
    Email author
  • Takahiro Yano
    • 2
  • Youko Suehiro
    • 3
  • Hiromi Iwasaki
    • 4
  • Michihiro Hidaka
    • 5
  • Maki Otsuka
    • 6
  • Kazutaka Sunami
    • 7
  • Nobumasa Inoue
    • 8
  • Morio Sawamura
    • 9
  • Takuo Ito
    • 10
  • Hiroatsu Iida
    • 1
  • Hirokazu Nagai
    • 1
    • 11
  1. 1.Department of HematologyNational Hospital Organization Nagoya Medical CenterNagoyaJapan
  2. 2.Department of HematologyNational Hospital Organization Tokyo Medical CenterTokyoJapan
  3. 3.Department of HematologyNational Hospital Organization Kyushu Cancer CenterFukuokaJapan
  4. 4.Department of HematologyNational Hospital Organization Kyushu Medical CenterFukuokaJapan
  5. 5.Department of HematologyNational Hospital Organization Kumamoto Medical CenterKumamotoJapan
  6. 6.Department of HematologyNational Hospital Organization Kagoshima Medical CenterKagoshimaJapan
  7. 7.Department of HematologyNational Hospital Organization Okayama Medical CenterOkayamaJapan
  8. 8.Department of HematologyNational Hospital Organization Osaka Medical CenterOsakaJapan
  9. 9.Department of HematologyNational Hospital Organization Shibukawa Medical CenterShibukawaJapan
  10. 10.Department of HematologyNational Hospital Organization Kure Medical CenterKureJapan
  11. 11.Clinical Research CenterNational Hospital Organization Nagoya Medical CenterNagoyaJapan
  12. 12.Department of HematologyGifu Prefectural Tajimi HospitalTajimiJapan

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