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International Journal of Hematology

, Volume 108, Issue 3, pp 344–347 | Cite as

CD3+ CD56+ EBER1+ atypical extraosseous plasmacytoma of the nasal cavity

  • Yayoi Ando
  • Akiko Miyagi Maeshima
  • Suguru Fukuhara
  • Shinichi Makita
  • Wataru Munakata
  • Tatsuya Suzuki
  • Dai Maruyama
  • Hirokazu Taniguchi
  • Koji Izutsu
Case Report
  • 175 Downloads

Abstract

We present a case of atypical extraosseous plasmacytoma (EP) with a plasmablastic morphology and CD3+ CD56+ Epstein–Barr virus-encoded RNA-1 (EBER1)+ phenotypes of the nasal cavity. A 51-year-old male attended a local hospital with a tumor located in his left nasal cavity that was histologically diagnosed as extranodal NK/T cell lymphoma, nasal type. We reviewed the specimens and re-biopsied the tumor, and confirmed that the tumor was positive for CD3, CD56, and EBER1; however, the tumor showed a plasmablastic morphology without necrosis and angiocentricity, and was positive for CD138, but negative for CD20 and PAX5. Given a plasmablastic morphology and EBER1 positivity, but a relatively low Ki67 index (30%), we diagnosed the case as atypical EP. The CHOP regimen was administered and complete remission achieved. This case indicated that EP should be considered as a differential diagnosis even when a tumor shows large cell morphology and is positive for CD3, CD56, and EBER1.

Keywords

CD3 CD56 Epstein–Barr virus Nasal cavity Plasmacytoma 

Notes

Acknowledgements

This work was supported in part by the Japan Agency for Medical Research and Development Fund (17ck0106349s0201) in Japan.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

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Copyright information

© The Japanese Society of Hematology 2018

Authors and Affiliations

  • Yayoi Ando
    • 1
    • 2
  • Akiko Miyagi Maeshima
    • 1
  • Suguru Fukuhara
    • 2
  • Shinichi Makita
    • 2
  • Wataru Munakata
    • 2
  • Tatsuya Suzuki
    • 2
  • Dai Maruyama
    • 2
  • Hirokazu Taniguchi
    • 1
  • Koji Izutsu
    • 2
  1. 1.Division of PathologyNational Cancer Center HospitalTokyoJapan
  2. 2.Department of HematologyNational Cancer Center HospitalTokyoJapan

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