Successful treatment of histiocytic sarcoma with cladribine and high-dose cytosine arabinoside in a child
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Histiocytic sarcoma, a rare hematopoietic neoplasm with evidence of histiocytic differentiation, is often refractory to conventional chemotherapy and radiotherapy, and its prognosis is generally dismal. The optimal management of this malignancy has not been established. We report a case of 8-year-old girl with histiocytic sarcoma involving the left femur. The tumor rapidly responded to a combination of cladribine and high-dose cytosine arabinoside, an aggressive salvage regimen for refractory Langerhans cell histiocytosis, and became impalpable during the first cycle. The patient has remained in complete remission more than 7 years from diagnosis.
KeywordsHistiocytic sarcoma Cladribine Cytosine arabinoside
We acknowledge the patient and her parents for giving us a written informed consent to the off-label use of the anticancer drugs and publication of this case report. We also acknowledge Drs. Ryosuke Hosokai, Sakiko Yoshida, and Junko Sakurada for patient care.
Compliance with ethical standards
Conflict of interest
CI received patent royalty from Juno Therapeutics. Other authors declare no conflict of interest.
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