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International Journal of Hematology

, Volume 102, Issue 5, pp 579–586 | Cite as

Increase in myeloid-derived suppressor cells (MDSCs) associated with minimal residual disease (MRD) detection in adult acute myeloid leukemia

  • Hui Sun
  • Yi Li
  • Zhi-fen Zhang
  • Ying Ju
  • Li Li
  • Bing-chang Zhang
  • Bin Liu
Original Article

Abstract

Myeloid-derived suppressor cells (MDSCs) are thought to help provide a cellular microenvironments in many solid tumors, in which transformed cells proliferate, acquire new mutations, and evade host immunosurveillance. In the present study, we found that MDSCs (CD33 + CD11b + HLA-DRlow/neg) in bone marrow were significantly increased in adult acute myeloid leukemia (AML) patients. MDSCs levels in newly diagnosed AML patients correlated well with extramedullary infiltration and plasma D-dimer levels. Remission rates in the MDSCs > 1500 group and MDSCs < 1500 group were 72.73 and 81.25 %, respectively. No significant differences were found between the two groups. MDSC levels in the complete remission group were significantly decreased after chemotherapy, while in the partial remission and non-remission groups, there were no significant differences. The level of MDSCs in the high minimal residual disease (MRD) group was significantly higher than that in the middle and low MRD groups. High levels of Wilms’ Tumor-1 (WT-1) protein were strongly correlated with higher bone marrow MDSC levels. In conclusion, we report here a population of immunosuppressive monocytes in the bone marrow of patients with AML characterized by the CD33highCD11b + HLA-DRlow/neg phenotype. These cells appear to impact the clinical course and prognosis of AML. This data may provide potentially important targets for novel therapies.

Keywords

Myeloid derived suppressor cells (MDSCs) Minimal residual disease (MRD) Adult acute myeloid leukemia (AML) Immune suppression 

Notes

Acknowledgments

This study was supported by grants from the National Natural Science Foundation of China (No. 81200575 and No. 81000731), the Promotive Research Fund for Excellent Young and Middle-Aged Scientists of Shandong Province (No. BS2012YY025) and the Shandong Provincial Key Clinical specialist construction projects (Lu Wei Yi [2013] 26).

Complaince with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© The Japanese Society of Hematology 2015

Authors and Affiliations

  • Hui Sun
    • 1
  • Yi Li
    • 2
  • Zhi-fen Zhang
    • 1
  • Ying Ju
    • 1
  • Li Li
    • 1
  • Bing-chang Zhang
    • 1
  • Bin Liu
    • 3
  1. 1.Department of Clinical LaboratoryShandong Provincial Hospital Affiliated to Shandong UniversityJinanPeople’s Republic of China
  2. 2.Department of Bone SurgeryShandong Provincial Hospital Affiliated to Shandong UniversityJinanPeople’s Republic of China
  3. 3.Department of Center LaboratoryShandong Provincial Hospital Affiliated to Shandong UniversityJinanPeople’s Republic of China

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