International Journal of Hematology

, Volume 102, Issue 5, pp 639–642 | Cite as

Imatinib-induced gastric antral vascular ectasia in three patients with chronic myeloid leukaemia

  • Jeremy Ong
  • David Yeung
  • Robin Filshie
  • Timothy P. Hughes
  • Harshal Nandurkar
Case Report


Imatinib is generally well tolerated, but gastric antral vascular ectasia (GAVE) remains a rare but significant complication of imatinib therapy. Whilst this complication has been described in other disease settings, only one other case of GAVE has been reported in a chronic myeloid leukaemia (CML) patient receiving imatinib. Herein, we present three CML patients with GAVE complicating imatinib therapy. In all cases, GAVE resolved only with cessation of imatinib. This confirms a causal relationship between GAVE and imatinib. GAVE should be considered as a possible cause of anaemia and upper gastrointestinal bleeding in patients receiving imatinib therapy.


Chronic myeloid leukaemia Tyrosine kinase inhibitor Imatinib Gastric antral vascular ectasia 


Compliance with ethical standards

Conflict of interest

D.Y. received research funding from Novartis and BMS and received honoraria from and participated in advisory boards of Novartis and BMS. T.H. received research funding from Ariad, CSL, Novartis and BMS and received honoraria from and participated in advisory boards of Ariad, Pfizer, Novartis and BMS. The remaining authors declare no competing financial interests.


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Copyright information

© The Japanese Society of Hematology 2015

Authors and Affiliations

  • Jeremy Ong
    • 1
  • David Yeung
    • 2
  • Robin Filshie
    • 1
  • Timothy P. Hughes
    • 2
    • 3
    • 4
  • Harshal Nandurkar
    • 1
  1. 1.Department of HaematologySt Vincent’s HospitalFitzroyAustralia
  2. 2.Division of HaematologySA PathologyAdelaideAustralia
  3. 3.University of AdelaideSouth AustraliaAustralia
  4. 4.South Australian Health and Medical Research InstituteSouth AustraliaAustralia

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