International Journal of Hematology

, Volume 102, Issue 5, pp 639–642 | Cite as

Imatinib-induced gastric antral vascular ectasia in three patients with chronic myeloid leukaemia

  • Jeremy Ong
  • David Yeung
  • Robin Filshie
  • Timothy P. Hughes
  • Harshal Nandurkar
Case Report

Abstract

Imatinib is generally well tolerated, but gastric antral vascular ectasia (GAVE) remains a rare but significant complication of imatinib therapy. Whilst this complication has been described in other disease settings, only one other case of GAVE has been reported in a chronic myeloid leukaemia (CML) patient receiving imatinib. Herein, we present three CML patients with GAVE complicating imatinib therapy. In all cases, GAVE resolved only with cessation of imatinib. This confirms a causal relationship between GAVE and imatinib. GAVE should be considered as a possible cause of anaemia and upper gastrointestinal bleeding in patients receiving imatinib therapy.

Keywords

Chronic myeloid leukaemia Tyrosine kinase inhibitor Imatinib Gastric antral vascular ectasia 

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Copyright information

© The Japanese Society of Hematology 2015

Authors and Affiliations

  • Jeremy Ong
    • 1
  • David Yeung
    • 2
  • Robin Filshie
    • 1
  • Timothy P. Hughes
    • 2
    • 3
    • 4
  • Harshal Nandurkar
    • 1
  1. 1.Department of HaematologySt Vincent’s HospitalFitzroyAustralia
  2. 2.Division of HaematologySA PathologyAdelaideAustralia
  3. 3.University of AdelaideSouth AustraliaAustralia
  4. 4.South Australian Health and Medical Research InstituteSouth AustraliaAustralia

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