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International Journal of Hematology

, Volume 99, Issue 4, pp 463–470 | Cite as

Soluble interleukin-2 receptor level on day 7 as a predictor of graft-versus-host disease after HLA-haploidentical stem cell transplantation using reduced-intensity conditioning

  • Katsuji Kaida
  • Kazuhiro Ikegame
  • Junko Ikemoto
  • Rie Murata
  • Reiko Irie
  • Satoshi Yoshihara
  • Shinichi Ishii
  • Masaya Okada
  • Takayuki Inoue
  • Hiroya Tamaki
  • Toshihiro Soma
  • Yoshihiro Fujimori
  • Shunro Kai
  • Hiroyasu OgawaEmail author
Original Article

Abstract

In the present study, we analyzed the kinetics of serum soluble interleukin-2 receptor (sIL-2R) using data from 77 patients undergoing HLA-haploidentical transplantation using reduced-intensity conditioning (RIC), who were at an advanced stage or at high risk for relapse, to clarify the usefulness of sIL-2R as a biomarker of acute graft-versus-host disease (GVHD). Anti-T-lymphocyte globulin and methylprednisolone were used as GVHD prophylaxis. While the median sIL-2R in 38 patients not developing GVHD was suppressed at levels <740 U/ml, sIL-2R in 25 patients developing severe GVHD peaked on day 11 (1,663 U/ml), and thereafter decreased to <1,000 U/ml after day 30. The occurrence of GVHD was not limited to times of high sIL-2R level, but occurred at any time point on the sIL-2R curve. Most patients developing GVHD, however, experienced a higher sIL-2R level early in their transplant course. The combination of RIC and glucocorticoids sufficiently suppressed sIL-2R levels after HLA-haploidentical transplantation. In a multivariate analysis to identify factors associated with GVHD, day 7 sIL-2R >810 U/ml was the only factor significantly associated with the occurrence of severe GVHD (p = 0.0101).

Keywords

Allogeneic stem cell transplantation Graft-versus-host disease Soluble interleukin-2 receptor Alloreactive response HLA-haploidentical transplantation 

Notes

Acknowledgments

We thank the medical, nursing, and laboratory staff of the participating departments for their contributions.

Conflict of interest

The authors declare no conflict of interest.

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Copyright information

© The Japanese Society of Hematology 2014

Authors and Affiliations

  • Katsuji Kaida
    • 1
  • Kazuhiro Ikegame
    • 1
  • Junko Ikemoto
    • 2
  • Rie Murata
    • 2
  • Reiko Irie
    • 2
  • Satoshi Yoshihara
    • 1
  • Shinichi Ishii
    • 1
  • Masaya Okada
    • 1
  • Takayuki Inoue
    • 1
  • Hiroya Tamaki
    • 1
  • Toshihiro Soma
    • 1
  • Yoshihiro Fujimori
    • 2
  • Shunro Kai
    • 2
  • Hiroyasu Ogawa
    • 1
    Email author
  1. 1.Division of Hematology, Department of Internal MedicineHyogo College of MedicineNishinomiyaJapan
  2. 2.Department of Transfusion MedicineHyogo College of MedicineNishinomiyaJapan

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