High-dose therapy and autologous stem cell transplantation in peripheral T-cell lymphoma: treatment outcome and prognostic factor analysis
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Peripheral T-cell lymphoma (PTCL) carries a poor prognosis with conventional treatment. We retrospectively analyzed data from 45 patients with PTCL who received high-dose therapy and autologous stem cell transplantation (HDT/ASCT) from 1990 to 2008 in our center. Eighteen patients underwent HDT/ASCT in complete remission to induction chemotherapy (CR1), and 27 patients underwent HDT/ASCT in other disease statuses. The median follow-up was 113.5 months (range 52.6–261.0) for surviving patients. The 5-year overall survival (OS) and progression-free survival (PFS) were 64 and 60 %, respectively. The 5-year OS for patients in CR1 and in other disease statuses was 89 and 47 %, respectively (P = 0.002), and 5-year PFS was 83 and 43 % (P = 0.007). In the subgroup excluding anaplastic large cell lymphoma, patients transplanted in CR1 also had significantly better 5-year OS (82 vs. 37 %, P = 0.009) and PFS (82 vs. 33 %, P = 0.008) than those transplanted in other disease statuses. Multivariate analysis showed that CR1 status was the only significant prognostic factor for OS (P = 0.040) and PFS (P = 0.040). These results support the use of HDT/ASCT consolidation in CR1 for PTCL patients. Prospective randomized trials are necessary to confirm the efficacy of this approach.
KeywordsHigh-dose therapy Autologous stem cell transplantation Peripheral T-cell lymphoma
This work was supported in part by Grants from the National Key Technologies Research and Development Program of China during the 9th Five-Year Plan Period [A201996103 96-906-01-12], the Ministry of Education Doctor Foundation of China [20010023018, 20050023045 and 200800230019], the Ying Dong Fok Foundation for Young College Teacher [B231996001], and the General Program of the National Natural Science Foundation of China . And we thank Ke-huan Luo, Feng Pan, Shi-kai Wu and Yin-yu Liu for their selfless and hard work in the study.
Conflict of interest
The authors declare that they have no conflict of interest.
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