International Journal of Hematology

, Volume 97, Issue 5, pp 610–616 | Cite as

Predictive factors associated with long-term effects of laparoscopic splenectomy for chronic immune thrombocytopenia

  • Mingjun Wang
  • Mengni Zhang
  • Jin Zhou
  • Zhong Wu
  • Ke Zeng
  • Bing Peng
  • Ting Niu
Original Article


The purpose of this study was to investigate the long-term effects of laparoscopic splenectomy (LS) for patients with chronic immune thrombocytopenia (ITP), and to identify predictive factors for promising hematological outcomes. We retrospectively analyzed the clinical records and follow-up data in patients who underwent LS for chronic ITP from November 2005 to August 2012. The related parameters were assessed by univariate and multivariate logistic regression analyses. The curve of life table was drawn to clarify the long-term response rate. Of the 92 included patients, 49 (53.3 %) patients achieved a complete response, 21 patients (22.8 %) a partial response, and the remaining 22 (23.9 %) showed no response to LS. Eleven patients relapsed within 1 year after LS, especially within 3 months (n = 7), while three patients relapsed 17, 26, and 28 months after LS, respectively. Long-term specific complications after LS were not observed. Platelet counts on postoperative month 3 (POM 3) is a significant independent predictor of long-term favorable hematological outcomes (P < 0.001). Based on our study, we conclude that LS is associated with promising long-term response for patients with chronic ITP, and platelet counts on POM 3 could be used as a predictor of long-term hematological outcome.


Laparoscopic splenectomy Chronic immune thrombocytopenia Follow-up 



The study was granted by the West China Hospital, Sichuan University.

Conflict of interest

No competing financial interests exist


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Copyright information

© The Japanese Society of Hematology 2013

Authors and Affiliations

  1. 1.Department of Hepatopancreatobiliary SurgeryWest China HospitalChengduChina
  2. 2.Department of PathologyWest China HospitalChengduChina
  3. 3.Department of Gastrointestinal SurgeryWest China HospitalChengduChina
  4. 4.Department of Hematology and Research Laboratory of HematologyWest China HospitalChengduChina

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