International Journal of Hematology

, Volume 97, Issue 4, pp 465–471

Low expression of microRNA-129-5p predicts poor clinical outcome in diffuse large B cell lymphoma (DLBCL)

  • Gustav Hedström
  • Ulf Thunberg
  • Mattias Berglund
  • Martin Simonsson
  • Rose-Marie Amini
  • Gunilla Enblad
Original Article

DOI: 10.1007/s12185-013-1303-2

Cite this article as:
Hedström, G., Thunberg, U., Berglund, M. et al. Int J Hematol (2013) 97: 465. doi:10.1007/s12185-013-1303-2

Abstract

Diffuse large B cell lymphoma (DLBCL) is a heterogeneous group of B cell lymphomas. MicroRNA expression provides a new and interesting tool for understanding the biology and clinical course of DLBCL. The present study presents microRNA-129-5p expression data from DLBCL patients treated with CHOP or R-CHOP. Patients with low microRNA-129-5p expression had a median survival of 23 months and a significantly shorter overall survival (P = 0.0042) compared to patients with high microRNA-129-5p expression, who had a median survival of 58 months. We also found that patients treated with R-CHOP only and displaying low microRNA-129-5p expression had a significantly shorter overall survival compared to patients with high microRNA-129-5p expression; all such patients were still alive at the time of last follow-up (P = 0.043). No significant difference was found among microRNA-129-5p expression in tumor tissue, the tissue surrounding the tumor, and normal controls. To our knowledge, this is the first report to show that the expression of microRNA-129-5p can affect the clinical outcome of DLBCL patients and that microRNA-129-5p may be involved in the biology of DLBCL development, although larger studies are necessary to confirm this. Further investigations may also help to elucidate the biological role of microRNA-129-5p in DLBCL.

Keywords

DLBCL microRNA-129-5p Prognosis 

Copyright information

© The Japanese Society of Hematology 2013

Authors and Affiliations

  • Gustav Hedström
    • 1
    • 3
  • Ulf Thunberg
    • 1
  • Mattias Berglund
    • 1
  • Martin Simonsson
    • 1
  • Rose-Marie Amini
    • 2
  • Gunilla Enblad
    • 1
  1. 1.Department of Radiology, Oncology, and Radiation SciencesUppsala UniversityUppsalaSweden
  2. 2.Department of Immunology, Genetics and PathologyUppsala UniversityUppsalaSweden
  3. 3.Rudbeck Laboratory, Departments of Oncology, Radiology and Clinical ImmunologyUppsala UniversityUppsalaSweden

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