International Journal of Hematology

, Volume 97, Issue 4, pp 491–497

Successful anticoagulant therapy for two pregnant PNH patients, and prospects for the eculizumab era

  • Yasuyoshi Morita
  • Jun-ichi Nishimura
  • Takahiro Shimada
  • Hirokazu Tanaka
  • Kentaro Serizawa
  • Yasuhiro Taniguchi
  • Mitsuhiro Tsuritani
  • Yuzuru Kanakura
  • Itaru Matsumura
Case Report


Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired stem cell disorder characterized by intravascular hemolysis and thrombosis. The most serious complication is thrombosis, the risk of which is augmented by the hyper-coagulable state that occurs during pregnancy; despite this risk, however, young female PNH patients often desire to have a baby. We recently experienced two successful deliveries in PNH patients, who were treated with anticoagulant therapy during their pregnancies. Meanwhile, given the potential benefit of eculizumab (Soliris), a humanized monoclonal antibody against C5, in reducing thrombosis and hemolysis, it represents a promising therapeutic option for the treatment of pregnant PNH patients in combination with, or in replacement of, anticoagulant therapy.


Paroxysmal nocturnal hemoglobinuria Pregnancy Low-molecular weight heparin Eculizumab 


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Copyright information

© The Japanese Society of Hematology 2013

Authors and Affiliations

  • Yasuyoshi Morita
    • 1
  • Jun-ichi Nishimura
    • 2
  • Takahiro Shimada
    • 1
  • Hirokazu Tanaka
    • 1
  • Kentaro Serizawa
    • 1
  • Yasuhiro Taniguchi
    • 1
  • Mitsuhiro Tsuritani
    • 3
  • Yuzuru Kanakura
    • 2
  • Itaru Matsumura
    • 1
  1. 1.Division of Hematology and Rheumatology, Department of Internal MedicineKinki University Faculty of MedicineOsaka-SayamaJapan
  2. 2.Department of Hematology and OncologyOsaka University, Graduate School of MedicineSuitaJapan
  3. 3.Department of Obstetrics and GynecologyKinki University Faculty of MedicineOsakaJapan

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