Successful salvage therapy using lenalidomide in a patient with relapsed multiple myeloma after allogeneic hematopoietic stem cell transplantation
Letter to the Editor
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A 34-year-old Japanese man was diagnosed in 2008 as having stage III symptomatic multiple myeloma (IgD-lambda type) as defined by the Durie Salmon and International staging system. Chromosomal analysis revealed a normal karyotype, although overexpression of Cyclin D1 was detected by reverse-transcription/real-time polymerase chain reaction assay. After three cycles of induction chemotherapy with vincristine, doxorubicin, and dexamethasone, he received high-dose melphalan therapy with adjunct autologous peripheral blood stem cell transplantation (PBSCT). A very good partial response (VGPR) was achieved, although he relapsed at 11 months after PBSCT. Four cycles of bortezomib and dexamethasone therapy were subsequently given, resulting in a second VGPR. In March 2010, he underwent allogeneic bone marrow transplantation (BMT) from an HLA-matched unrelated donor. The conditioning regimen consisted of fludarabine (30 mg/m 2/day on days −8 to −3) and intravenous busulfan (3.2 mg/kg/day on...
KeywordsMultiple Myeloma Tacrolimus Bortezomib Lenalidomide Acute GVHD
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Conflict of interest
SI has received research funding from Celgene Corporation.
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© The Japanese Society of Hematology 2013