International Journal of Hematology

, Volume 97, Issue 3, pp 382–387

Lymphocytopenia is associated with an increased risk of severe infections in patients with multiple myeloma treated with bortezomib-based regimens

  • Sung-Hoon Jung
  • Soo-Young Bae
  • Jae-Sook Ahn
  • Seung-Ji Kang
  • Deok-Hwan Yang
  • Yeo-Kyeoung Kim
  • Hyeoung-Joon Kim
  • Je-Jung Lee
Original Article

DOI: 10.1007/s12185-013-1270-7

Cite this article as:
Jung, SH., Bae, SY., Ahn, JS. et al. Int J Hematol (2013) 97: 382. doi:10.1007/s12185-013-1270-7

Abstract

Bortezomib is a proteasome inhibitor with potent antimyeloma activity in relapsed/refractory multiple myeloma (MM) patients. We evaluated the types and factors affecting the onset of infectious complications and mortality owing to infection in MM patients treated with bortezomib-based regimens. We reviewed 139 patients with MM treated with regimens containing bortezomib in order to assess the types and factors affecting the development of severe infections. Infections occurred in 56 (40.3 %) of 139 patients and 83 (7.8 %) cases of the 1,069 evaluable cycles. Severe infections developed in 43 (30.9 %) patients and ten patients (7.1 %) died during bortezomib-based treatment. Multivariate analysis determined lymphocytopenia grade 3–4 (OR 3.17, 95 % CI 1.38–7.31, P = 0.007) and number of cycles ≤8 (OR 3.91, 95 % CI 1.39–11.02, P = 0.010) as risk factors associated with increased severe infection. This study showed that MM patients who received bortezomib-based regimens are at a higher risk of severe infections within eight cycles of treatment during especially severe lymphocytopenic periods. MM patients treated with bortezomib-based regimens should be closely monitored for the development of infectious complications during lymphocytopenia.

Keywords

Multiple myeloma Bortezomib Infection 

Copyright information

© The Japanese Society of Hematology 2013

Authors and Affiliations

  • Sung-Hoon Jung
    • 1
  • Soo-Young Bae
    • 1
  • Jae-Sook Ahn
    • 1
  • Seung-Ji Kang
    • 2
  • Deok-Hwan Yang
    • 1
  • Yeo-Kyeoung Kim
    • 1
  • Hyeoung-Joon Kim
    • 1
  • Je-Jung Lee
    • 1
  1. 1.Department of Hematology-OncologyChonnam National University Hwasun HospitalHwasunRepublic of Korea
  2. 2.Department of Infectious DiseaseChonnam National University Hwasun HospitalHwasunRepublic of Korea

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