International Journal of Hematology

, Volume 97, Issue 2, pp 240–245 | Cite as

Primary testicular lymphoma: experience with 13 cases and literature review

Original Article


To summarize the clinicopathological features, therapeutic regimens, and outcomes for patients with primary testicular lymphoma (PTL), we retrospectively reviewed the medical records of 13 patients diagnosed with PTL between 2001 and 2012 at our hospital. Average age at diagnosis was 62.2 ± 13.9 years, and all patients presented with painless testicular swelling. Diffuse large B-cell lymphoma was the dominant histotype (69.2 %). All 13 patients were treated with inguinal orchiectomy and received chemotherapy and/or radiotherapy. Complete follow-up data were available for 10 patients with an average follow-up duration of 28.4 ± 30.9 months. Seven patients were evaluated as Ann Arbor stage I or II, and three as stage III or IV. Eight patients were found to have hypoechogenic and hypervascular signals in the testis on ultrasound examination. Complete remission was achieved in six patients, and four patients who were still undergoing chemotherapy during the last follow-up showed no signs of relapse. Of the 10 patients with complete follow-up records, three had relapses, which occurred in the CNS, epiglottis, and the nasal cavity. Time to relapse in these cases was 2, 7, and 11 months, respectively (3/10). The mean progression-free survival was 22.57 months (range 1.1–101.9 months).


Primary testicular lymphoma Large B-cell lymphoma Testicular hydrocele Treatment Patient outcomes 





β-Human chorionic gonadotropin


Central nervous system


Computed tomography


Complete remission


Diffuse large B-cell lymphoma


Dexamethasone, ifosfamide, cisplatin, and etoposide


Etoposide, solumedrol (methylprednisolone), ara-C (high-dose cytarabine), and cisplatin


International Prognostic Index


Magnetic resonance imaging


Non-Hodgkin’s lymphoma


Overall survival


Progression-free survival


Primary testicular lymphoma



The authors were supported by a Grant (WC) from the National Natural Science Foundation of China (81000817).

Conflict of interest

The authors have no conflicts of interest to declare.

Supplementary material

12185_2013_1261_MOESM1_ESM.doc (74 kb)
Supplementary material 1 (DOC 74 kb)


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Copyright information

© The Japanese Society of Hematology 2013

Authors and Affiliations

  • Chu Wang
    • 1
  • Hai Wang
    • 1
  • Qinghai Wang
    • 1
  • Bingbing Shi
    • 1
  1. 1.Department of Urology, Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC)BeijingChina

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