International Journal of Hematology

, Volume 96, Issue 4, pp 513–515

A rare case of intracerebral hemorrhage complicating heparin-induced thrombocytopenia with thrombosis: a clinical dilemma ameliorated by novel use of plasmapheresis

  • Nay Min Tun
  • Zaw Min Bo
  • Meena Ahluwalia
  • Elizabeth Guevara
  • Gina M. Villani
Case Report

DOI: 10.1007/s12185-012-1161-3

Cite this article as:
Tun, N.M., Bo, Z.M., Ahluwalia, M. et al. Int J Hematol (2012) 96: 513. doi:10.1007/s12185-012-1161-3

Abstract

We report a case of heparin-induced thrombocytopenia with thrombosis type 2 (HITT 2) that was first complicated by intracerebral hemorrhage (ICH) and later by deep venous thrombosis (DVT). HITT 2 was initially managed conventionally with argatroban, which was stopped when ICH was discovered. The size of ICH increased despite attempts to increase platelet count by platelet transfusions. At this point of the clinical dilemma, plasma exchange was utilized effectively to recover the platelet count and deter ICH progression. The clinical course was later complicated by DVT, for which fondaparinux was given. This case represents a rare clinical scenario of HITT 2 resulting in progressive ICH that excluded the use of antithrombotic agents as part of HITT therapy. We believe that the use of plasmapheresis as a salvage procedure in such situations is effective and life-saving. Physicians should be aware of plasmapheresis as a therapeutic option in HITT 2 in cases in which anticoagulation is contraindicated.

Keywords

Heparin-induced thrombocytopenia Intracerebral hemorrhage Thrombosis Plasmapheresis Case report 

Copyright information

© The Japanese Society of Hematology 2012

Authors and Affiliations

  • Nay Min Tun
    • 1
  • Zaw Min Bo
    • 1
  • Meena Ahluwalia
    • 1
  • Elizabeth Guevara
    • 1
  • Gina M. Villani
    • 1
  1. 1.Division of Hematology and OncologyThe Brooklyn Hospital CenterBrooklynUSA

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