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International Journal of Hematology

, Volume 94, Issue 5, pp 435–442 | Cite as

Molecular mechanisms of HTLV-1 infection and pathogenesis

  • Junichiro YasunagaEmail author
  • Masao Matsuoka
Progress in Hematology Memorial PIM: adult T-cell leukemia―from discovery to recent progress

Abstract

Human T cell leukemia virus type 1 (HTLV-1) is an etiological pathogen of several human diseases, including adult T-cell leukemia (ATL), HTLV-1-associated myelopathy (HAM)/tropical spastic paraparesis (TSP), and inflammatory disorders such as uveitis and dermatitis. HTLV-1 spreads mainly through cell-to-cell transmission, induces clonal proliferation of infected T cells in vivo, and after a long latent period, a subset of HTLV-1 carriers develop ATL. Understanding the molecular mechanisms of infection and oncogenesis is important for the development of new strategies of prophylaxis and molecular-targeted therapies, since ATL has a poor prognosis, despite intensive chemotherapy. In this review, we will summarize recent progress in HTLV-1 research, and especially novel findings on viral transmission and leukemogenic mechanisms by two viral oncogenes, HBZ and tax.

Keywords

Human T-cell leukemia virus type 1 (HTLV-1) Adult T-cell leukemia (ATL) HTLV-1 bZIP factor (HBZ) HBZ transgenic mouse FoxP3 Tax 

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Copyright information

© The Japanese Society of Hematology 2011

Authors and Affiliations

  1. 1.Laboratory of Virus Control, Institute for Virus ResearchKyoto UniversityKyotoJapan

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