International Journal of Hematology

, Volume 94, Issue 1, pp 24–32

Reactive oxygen species and hematopoietic stem cell senescence

  • Lijian Shao
  • Hongliang Li
  • Senthil K. Pazhanisamy
  • Aimin Meng
  • Yong Wang
  • Daohong Zhou
Progress in Hematology Hematopoietic stem cell aging
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Abstract

Hematopoietic stem cells (HSCs) are responsible for sustaining hematopoietic homeostasis and regeneration after injury for the entire lifespan of an organism through self-renewal, proliferation, differentiation, and mobilization. Their functions can be affected by reactive oxygen species (ROS) that are produced endogenously through cellular metabolism or after exposure to exogenous stress. At physiological levels, ROS function as signal molecules which can regulate a variety of cellular functions, including HSC proliferation, differentiation, and mobilization. However, an abnormal increase in ROS production occurs under various pathological conditions, which can inhibit HSC self-renewal and induce HSC senescence, resulting in premature exhaustion of HSCs and hematopoietic dysfunction. This review aims to provide a summary of a number of recent findings regarding the cellular sources of ROS in HSCs and the mechanisms of action whereby ROS induce HSC senescence. In particular, we highlight the roles of the p38 mitogen-activated protein kinase (p38)-p16Ink4a (p16) pathway in mediating ROS-induced HSC senescence.

Keywords

Reactive oxygen species Hematopoietic stem cells NADPH oxidase p38 p16 Senescence 

Copyright information

© The Japanese Society of Hematology 2011

Authors and Affiliations

  • Lijian Shao
    • 1
  • Hongliang Li
    • 1
    • 2
  • Senthil K. Pazhanisamy
    • 1
  • Aimin Meng
    • 2
  • Yong Wang
    • 3
  • Daohong Zhou
    • 1
    • 4
  1. 1.Division of Radiation Health, Department of Pharmaceutical SciencesUniversity of Arkansas for Medical SciencesLittle RockUSA
  2. 2.Department of Biochemistry and Molecular Biology, Institute of Radiation MedicineChinese Academy of Medical SciencesTianjinChina
  3. 3.Department of PathologyMedical University of South CarolinaCharlestonUSA
  4. 4.Winthrop P. Rockefeller Cancer InstituteUniversity of Arkansas for Medical SciencesLittle RockUSA

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