International Journal of Hematology

, Volume 93, Issue 5, pp 677–680

Autologous stem cell transplantation in a rare multicentric Castleman disease of the plasma cell variant

  • Yuval Tal
  • Guy Haber
  • Matan J. Cohen
  • Micci Phillips
  • Gail Amir
  • Dina Ben-Yehuda
  • Arie Ben-Yehuda
Case Report


We present a case of a 52-year-old male who was evaluated due to anorexia, persistent diarrhea, weight loss, and liver enzyme elevations, with no hematologic laboratory abnormalities. Imaging modalities revealed several tissue lesions involving the pancreas, the right kidney, and an axillary lymph node. Diagnosis of Castleman disease was reached only due to the tissue obtained from the lymph node. Chemotherapy and immunosuppression led to a short remission. The patient underwent autologous stem cell transplantation, and has since been in remission. This case demonstrates the cryptogenic and chameleon-like nature of Castleman disease. Challenges in treating Castleman disease patients reflect current limitations and the need for a greater understanding of disease pathogenesis.


Castleman disease Autologous stem cell transplantation 



Castleman’s disease


Multicentric Castleman’s disease


Human immunodeficiency virus


Computed tomography


Positron emission tomography


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Copyright information

© The Japanese Society of Hematology 2011

Authors and Affiliations

  • Yuval Tal
    • 1
  • Guy Haber
    • 1
  • Matan J. Cohen
    • 1
  • Micci Phillips
    • 1
  • Gail Amir
    • 2
  • Dina Ben-Yehuda
    • 3
  • Arie Ben-Yehuda
    • 1
  1. 1.Department of Internal Medicine CHadassah-Hebrew University Medical CenterJerusalemIsrael
  2. 2.Department of PathologyHadassah-Hebrew University Medical CenterJerusalemIsrael
  3. 3.Department of HematologyHadassah-Hebrew University Medical CenterJerusalemIsrael

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