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International Journal of Hematology

, Volume 91, Issue 4, pp 670–672 | Cite as

Successful unrelated donor cord blood transplantation for chronic granulomatous disease

  • Tang-Her Jaing
  • Wen I Lee
  • Po-Jen Cheng
  • Shih-Hsiang Chen
  • Jing-Long Huang
  • Yung-Kuei SoongEmail author
Case Report

Abstract

This report exemplified a success of unrelated donor cord blood transplantation (CBT) in a 4-month-old boy with chronic granulomatous disease (CGD). Following Bu14/Cy200/ATG conditioning, the patient received an HLA 2-locus-mismatched cord blood unit, and the total number of infused nucleated cells was 11.52 × 107/kg. Neutrophil engraftment was achieved on day +13, and a platelet count greater than 20 × 109/L was achieved on day +50. The neutrophil oxidative burst was 100% normal with full donor lymphocyte reconstitution at 8 months post-transplant. This case highlights that unrelated donor CBT for CGD is potentially safe and feasible, even in early infancy, when an appropriately matched related or unrelated donor is unavailable.

Keywords

Chronic granulomatous disease Unrelated cord blood transplantation Young infant 

Notes

Acknowledgments

This report was in part supported by the following grants: The Chang-Gung Medical Research Progress Grant (CMRPG 33020 & 340222) and the National Science Council Grant (96-2314-B-182A-053-MY2).

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Copyright information

© The Japanese Society of Hematology 2010

Authors and Affiliations

  • Tang-Her Jaing
    • 1
  • Wen I Lee
    • 2
  • Po-Jen Cheng
    • 3
  • Shih-Hsiang Chen
    • 1
  • Jing-Long Huang
    • 2
  • Yung-Kuei Soong
    • 3
    Email author
  1. 1.Division of Hematology and Oncology, Department of PediatricsChang Gung Children’s Hospital, Chang Gung UniversityTaoyuanTaiwan
  2. 2.Division of Allergy, Immunology, and Rheumatology, Department of PediatricsChang Gung Children’s Hospital, Chang Gung UniversityTaoyuanTaiwan
  3. 3.Lin-Kou Medical Center, Department of Obstetrics and GynecologyChang Gung Memorial Hospital, Chang Gung UniversityTaoyuanTaiwan

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