Successful unrelated donor cord blood transplantation for chronic granulomatous disease
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This report exemplified a success of unrelated donor cord blood transplantation (CBT) in a 4-month-old boy with chronic granulomatous disease (CGD). Following Bu14/Cy200/ATG conditioning, the patient received an HLA 2-locus-mismatched cord blood unit, and the total number of infused nucleated cells was 11.52 × 107/kg. Neutrophil engraftment was achieved on day +13, and a platelet count greater than 20 × 109/L was achieved on day +50. The neutrophil oxidative burst was 100% normal with full donor lymphocyte reconstitution at 8 months post-transplant. This case highlights that unrelated donor CBT for CGD is potentially safe and feasible, even in early infancy, when an appropriately matched related or unrelated donor is unavailable.
KeywordsChronic granulomatous disease Unrelated cord blood transplantation Young infant
This report was in part supported by the following grants: The Chang-Gung Medical Research Progress Grant (CMRPG 33020 & 340222) and the National Science Council Grant (96-2314-B-182A-053-MY2).