International Journal of Hematology

, Volume 91, Issue 3, pp 384–391 | Cite as

Hematopoiesis from pluripotent stem cell lines

  • Hiroshi Sakamoto
  • Kiyomi Tsuji-Tamura
  • Minetaro Ogawa
Progress in Hematology ES and iPS cells, attractive stem cells for regenerative medicine


Embryonic stem cells (ESCs) can differentiate into various types of hematopoietic cells (HPCs) when placed in an appropriate environment. Various methods for the differentiation of ESCs into specific HPC lineages have been developed using mouse ESCs. These ESC-differentiation methods have been utilized also as an in vitro model to investigate hematopoiesis in embryos and they provided critical perceptions into it. These methods have been adapted for use with human ESCs, which have the possibility of being employed in regenerative medicine; further improvement of these methods may lead to the efficient production of HPCs for use in transfusions. The generation of transplantable hematopoietic stem cells is a medical goal that is still difficult to achieve. Recently, induced pluripotent stem (iPS) cells have been established from differentiated cells. Thereby, iPS cells have expanded further possibilities of the use of pluripotent stem cell lines in clinical application. Indeed, iPS cells have been established from cells with disease genes and those which have undergone reprogramming and targeting have generated phenotypically normal HPCs. Here, we mainly summarize the recent progress in research on hematopoiesis conducted with ESCs and iPS cells.


ES cell iPS cell Hematopoiesis Hematopoietic stem cell 


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Copyright information

© The Japanese Society of Hematology 2010

Authors and Affiliations

  • Hiroshi Sakamoto
    • 1
  • Kiyomi Tsuji-Tamura
    • 1
  • Minetaro Ogawa
    • 1
  1. 1.Department of Cell Differentiation, Institute of Molecular Embryology and GeneticsKumamoto UniversityKumamotoJapan

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