International Journal of Hematology

, Volume 91, Issue 2, pp 303–309

The clinical characteristics of CD7+ CD56+ acute myeloid leukemias other than M0

  • Ritsuro Suzuki
  • Shigeki Ohtake
  • Jin Takeuchi
  • Masami Nagai
  • Yoshihisa Kodera
  • Motohiro Hamaguchi
  • Shuichi Miyawaki
  • Takahiro Karasuno
  • Shigetaka Shimodaira
  • Ryuzo Ohno
  • Shigeo Nakamura
  • Tomoki Naoe
Original Article

Abstract

Immunological phenotyping of acute leukemia have provided enormous and important information for the classification and lineage determination of leukemia. Forty-nine patients with CD7+ CD56+ acute myeloid leukemia (AML) were analyzed. There were 17 patients of M0, which corresponded to myeloid/NK cell precursor acute leukemia, and 32 patients of AML other than M0 (9 each for M1 and M2, one for M3, 3 for M4, 4 for M5 and 6 for M7). Age distribution was similar between these two groups, but CD7+ CD56+ M0 showed significant male predominance than CD7+ CD56+ M1–M7 (M:F = 15:2 vs. 15:17, P = 0.006). The disease localization and the hematological manifestations were different, showing fewer white blood cell counts and circulating leukemic blasts, less anemia, less thrombocytopenia and more frequent extramedullary involvement in M0 group. The prognosis was poor in both groups, and there was no statistical difference. These findings suggest that extramedullary involvement of myeloid/NK cell precursor acute leukemia is not directly derived from the presence of CD7 and CD56 antigens on leukemic cells. The poor prognosis of CD7+ CD56+ M1–M7 suggests that this phenotype may act as a prognostic factor for AML, but this should be confirmed in further studies.

Keywords

Acute myeloid leukemia Immunophenotyping CD7 CD56 

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Copyright information

© The Japanese Society of Hematology 2010

Authors and Affiliations

  • Ritsuro Suzuki
    • 1
  • Shigeki Ohtake
    • 2
  • Jin Takeuchi
    • 3
  • Masami Nagai
    • 4
  • Yoshihisa Kodera
    • 5
  • Motohiro Hamaguchi
    • 6
  • Shuichi Miyawaki
    • 7
  • Takahiro Karasuno
    • 8
  • Shigetaka Shimodaira
    • 9
  • Ryuzo Ohno
    • 10
  • Shigeo Nakamura
    • 11
  • Tomoki Naoe
    • 12
  1. 1.Department of HSCT Data ManagementNagoya University School of MedicineNagoyaJapan
  2. 2.Third Department of Internal MedicineKanazawa University School of MedicineKanazawaJapan
  3. 3.Department of Internal MedicineNihon University School of MedicineTokyoJapan
  4. 4.First Department of Internal MedicineKagawa Medical UniversityTakamatsuJapan
  5. 5.Department of Internal MedicineJapanese Red Cross Nagoya First HospitalNagoyaJapan
  6. 6.Department of HematologyNational Hospital Organization, Nagoya Medical CenterNagoyaJapan
  7. 7.Department of Internal MedicineSaiseikai Maebashi HospitalMaebashiJapan
  8. 8.Department of Internal MedicineOsaka Medical Center for Cancer and Cardiovascular DiseasesOsakaJapan
  9. 9.Department of Internal MedicineJapanese Red Cross Nagano HospitalNaganoJapan
  10. 10.Aichi Cancer CenterNagoyaJapan
  11. 11.Department of PathologyNagoya University School of MedicineNagoyaJapan
  12. 12.Department of Hematology and OncologyNagoya University School of MedicineNagoyaJapan

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