International Journal of Hematology

, Volume 89, Issue 4, pp 529–532 | Cite as

Histiocytic/dendritic cell sarcoma arising from follicular lymphoma involving the bone: a case report and review of literature

  • Da Zhang
  • Joseph McGuirk
  • Siddhartha Ganguly
  • Diane L. Persons
Case Report
First Online:
Received:
Revised:
Accepted:

Abstract

Histiocytic/dendritic cell sarcomas arising from follicular lymphoma are very rare and poorly understood lesions. We describe a case, which is unique in that it presented with a hipbone lesion simultaneously with axillary lymphadenopathy. Biopsy of the axillary lymph node showed a low-grade follicular lymphoma. The hipbone lesion was comprised two cell populations, one representing diffuse large B cell lymphoma and the other a histiocytic/dendritic sarcoma. The cells of all three lesions contained an IGH/BCL2 rearrangement, suggesting that both diffuse large B cell lymphoma and histiocytic/dendritic sarcoma differentiation developed from the same low grade precursor (follicular lymphoma). This case illustrates that sarcomatous transdifferentiation of follicular lymphoma can be an unpredictable local phenomenon and that it can occur extra nodally in the bone marrow. It may also occur concurrently with the progression of follicular lymphoma to a diffuse large B cell lymphoma.

Keywords

Follicular lymphoma Histiocytic/dendritic cell sarcomas Diffuse large B cell lymphoma t(14;18) 
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Copyright information

© The Japanese Society of Hematology 2009

Authors and Affiliations

  • Da Zhang
    • 1
  • Joseph McGuirk
    • 2
  • Siddhartha Ganguly
    • 2
  • Diane L. Persons
    • 1
  1. 1.Department of Pathology and Laboratory of MedicineKansas University Medical CenterKansas CityUSA
  2. 2.Department of MedicineKansas University Medical CenterKansas CityUSA

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