International Journal of Hematology

, Volume 88, Issue 5, pp 596–598

Successful cord blood transplantation for mycosis fungoides

  • Takuya Fukushima
  • Kensuke Horio
  • Emi Matsuo
  • Daisuke Imanishi
  • Reishi Yamasaki
  • Hideki Tsushima
  • Yoshitaka Imaizumi
  • Koichi Ohshima
  • Tomoko Hata
  • Shinichiro Yoshida
  • Yasushi Miyazaki
  • Masao Tomonaga
Case Report

DOI: 10.1007/s12185-008-0190-4

Cite this article as:
Fukushima, T., Horio, K., Matsuo, E. et al. Int J Hematol (2008) 88: 596. doi:10.1007/s12185-008-0190-4

Abstract

A 26-year-old female diagnosed as mycosis fungoides (MF, clinical stage IV) was treated with single-agent chemotherapy, multi-drug chemotherapy and unrelated bone marrow transplantation with reduced-intensity conditioning (engraftment failure), resulting in failure. Unrelated cord blood transplantation (CBT) as second transplantation following myeloablative conditioning brought complete remission (CR), but relapse of MF occurred 3 months after transplantation. However, discontinuation of immune suppressant led to the regression of MF regions and to second CR that continued for more than 23 months. This is the first report of successful CBT for MF, suggesting the graft-versus-MF effect in a setting of CBT.

Keywords

Mycosis fungoides Cord blood transplantation Graft-versus-lymphoma effect 

Copyright information

© The Japanese Society of Hematology 2008

Authors and Affiliations

  • Takuya Fukushima
    • 1
  • Kensuke Horio
    • 1
  • Emi Matsuo
    • 1
  • Daisuke Imanishi
    • 1
  • Reishi Yamasaki
    • 1
  • Hideki Tsushima
    • 1
  • Yoshitaka Imaizumi
    • 1
  • Koichi Ohshima
    • 2
  • Tomoko Hata
    • 1
  • Shinichiro Yoshida
    • 3
  • Yasushi Miyazaki
    • 1
  • Masao Tomonaga
    • 1
  1. 1.Department of Hematology and Molecular Medicine Unit, Atomic Bomb Disease InstituteNagasaki University Graduate School of Biomedical SciencesNagasakiJapan
  2. 2.Department of Pathology, School of MedicineKurume UniversityKurumeJapan
  3. 3.Department of Internal MedicineNagasaki Medical CenterOhmuraJapan

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