Periostin and bone marrow fibrosis

  • Eijiro Oku
  • Taisuke Kanaji
  • Yuka Takata
  • Koichi Oshima
  • Ritsuko Seki
  • Satoshi Morishige
  • Rie Imamura
  • Korenori Ohtsubo
  • Michitoshi Hashiguchi
  • Koichi Osaki
  • Kazuaki Yakushiji
  • Kohji Yoshimoto
  • Hideaki Ogata
  • Hirofumi Hamada
  • Kenji Izuhara
  • Michio Sata
  • Takashi Okamura
Original Article

Abstract

Periostin is a secreted protein that shares structural homology with the insect axon guidance protein fasciclin 1. Periostin is expressed predominantly in collagen-rich fibrous connective tissues that are subjected to constant mechanical stresses. We have shown previously that periostin is a novel component of subepithelial fibrosis in bronchial asthma. Here, we investigated the relationship between periostin and bone marrow (BM) fibrosis. Periostin was expressed in the stroma and stromal cells of BM fibrosis specimens and to a great extent its expression levels correlated closely to the grade of fibrosis, as estimated by silver staining. However, in the present study, we found no relationship between plasma periostin levels and the extent of BM fibrosis. We also demonstrated that periostin is secreted by human BM hTERT stromal cells and that its secretion is enhanced by TGF-β, a cytokine produced by clonal proliferation of megakaryocytes and/or monocytes. These results indicate that periostin is a component of BM fibrosis and that it may play a role in the disease progression.

Keywords

Periostin Fibrosis Myelofibrosis TGF-β 

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Copyright information

© The Japanese Society of Hematology 2008

Authors and Affiliations

  • Eijiro Oku
    • 1
  • Taisuke Kanaji
    • 1
  • Yuka Takata
    • 1
  • Koichi Oshima
    • 2
  • Ritsuko Seki
    • 1
  • Satoshi Morishige
    • 1
  • Rie Imamura
    • 1
  • Korenori Ohtsubo
    • 1
  • Michitoshi Hashiguchi
    • 1
  • Koichi Osaki
    • 1
  • Kazuaki Yakushiji
    • 1
  • Kohji Yoshimoto
    • 1
  • Hideaki Ogata
    • 1
  • Hirofumi Hamada
    • 3
  • Kenji Izuhara
    • 4
  • Michio Sata
    • 5
  • Takashi Okamura
    • 1
  1. 1.Division of HaematologyKurume University School of MedicineFukuokaJapan
  2. 2.Department of PathologyKurume University School of MedicineKurumeJapan
  3. 3.Department of Molecular MedicineSapporo Medical University School of MedicineSapporoJapan
  4. 4.Division of Medical Biochemistry, Department of Biomolecular SciencesSaga Medical SchoolSagaJapan
  5. 5.Division of Gastroenterology, Department of MedicineKurume University School of MedicineKurumeJapan

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