International Journal of Hematology

, Volume 87, Issue 4, pp 434–439 | Cite as

Virus reactivation in high-risk non-Hodgkin’s lymphoma patients after autologous CD34+-selected peripheral blood progenitor cell transplantation

  • Peng-Chan Lin
  • Ming-Yang Lee
  • Jen-Tsun Lin
  • Liang-Tsai Hsiao
  • Po-Min Chen
  • Tzeon-Jye Chiou
Case Report

Abstract

CD34+-selected peripheral blood progenitor cells (PBPCs) may not only reduce contaminated tumor cells but also compromise immunologic reconstitution and increase incidence of infections after transplantation. We analyzed the incidence of virus reactivation in CD34+-selected PBPCs autologous transplantation. From December 2001 to December 2004, ten high-risk aggressive non-Hodgkin’s lymphoma (NHL) patients were enrolled in a program of high-dose chemotherapy plus autologous CD34+-selected PBPCs support. Viral screening studies, including clinical symptoms, physical examinations, hepatitis B virus (HBV)-DNA, cytomegalovirus (CMV)-polymerase chain reaction (PCR), rapid diagnosis of fluorescent antibody stain for herpes-simplex virus (HSV), and viral culture from blood, fluid or tissue were performed weekly during the first 3 months and then monthly for 1 year. Two of four patients (50%) who were HBV carriers developed HBV reactivation. The other two HBV carriers who received prophylactic lamivudine therapy did not develop HBV reactivation. Two patients (20%) developed cytomegalovirus (CMV) infection, and three patients (30%) developed HSV infection in total ten serum-positive patients. The possibility of virus reactivation might increase in NHL patients undergoing autologous CD34+-selected PBPC transplantation. Administering prophylactic antivirus therapy and closely following patient’s clinical viral complications should be considered.

Keywords

CD34+-selected PBPCs Virus reactivation Non-Hodgkin’s lymphoma Autotransplantation 

Notes

Acknowledgments

We greatly thank the grant supports from Taiwan Clinical Cancer Research Foundation, Taipei, Taiwan and Taipei Veterans General Hospital in this study.

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Copyright information

© The Japanese Society of Hematology 2008

Authors and Affiliations

  • Peng-Chan Lin
    • 1
    • 2
  • Ming-Yang Lee
    • 1
  • Jen-Tsun Lin
    • 1
  • Liang-Tsai Hsiao
    • 1
  • Po-Min Chen
    • 1
  • Tzeon-Jye Chiou
    • 1
    • 3
  1. 1.Division of Hematology and Oncology, Department of MedicineTaipei Veterans General Hospital and National Yang-Ming University School of MedicineTaipeiTaiwan
  2. 2.Division of Hematology and Oncology, Department of MedicineNational Cheng Kung University HospitalTainanTaiwan
  3. 3.Division of Transfusion Medicine, Department of MedicineTaipei Veterans General Hospital and National Yang-Ming University School of MedicineTaipeiTaiwan

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