International Journal of Hematology

, Volume 87, Issue 1, pp 56–59

Dramatic remission of anemia after thymectomy in a patient of idiopathic myelofibrosis with thymoma

  • Ying-Yih Shih
  • Liang-Tsai Hsiao
  • Ching-Fen Yang
  • Yu-Chung Wu
  • Tzeon-Jye Chiou
Case Report


Anemia is one of the characteristics of idiopathic myelofibrosis (IMF), and malignant thymoma is usually associated with various hematologic disorders, including anemia, pancytopenia, and hypogammaglobulinemia. However, the relationship between IMF and malignant thymoma has not been published before. Here, we report a 48-year-old woman who was initially diagnosed of IMF with severe anemia and transfusion dependent. Five years later, malignant thymoma was found when she was examined for chronic cough. After performing extended thymectomy, her anemia dramatically recovered to normal and sustained for 2 years till last follow-up. Her splenomegaly and myelofibrosis were also improved. We hypothesized that her malignant thymoma induced the progression of IMF, especially in anemia.


Anemia Danazol Idiopathic myelofibrosis Thymectomy Thymoma 


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Copyright information

© The Japanese Society of Hematology 2007

Authors and Affiliations

  • Ying-Yih Shih
    • 1
    • 4
  • Liang-Tsai Hsiao
    • 1
  • Ching-Fen Yang
    • 2
  • Yu-Chung Wu
    • 3
  • Tzeon-Jye Chiou
    • 1
  1. 1.Division of Hematology and Oncology, Department of MedicineTaipei Veterans General Hospital, National Yang-Ming University School of MedicineTaipeiTaiwan
  2. 2.Department of PathologyTaipei Veterans General HospitalTaipeiTaiwan
  3. 3.Division of Thoracic Surgery, Department of SurgeryTaipei Veterans General HospitalTaipeiTaiwan
  4. 4.Division of Hematology and Oncology, Department of MedicineCathay General HospitalTaipeiTaiwan

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