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Current Reviews in Musculoskeletal Medicine

, Volume 11, Issue 4, pp 558–565 | Cite as

The Economics and Regulation of PRP in the Evolving Field of Orthopedic Biologics

  • Ian A. Jones
  • Ryan C. Togashi
  • C. Thomas VangsnessJrEmail author
Protein-Rich Plasma: From Bench to Treatment of Arthritis (S Choate and J Tokish, section editors)
Part of the following topical collections:
  1. Topical Collection on Protein-Rich Plasma: From Bench to Treatment of Arthritis

Abstract

Purpose of Review

This review provides an update on the current status of platelet-rich plasma (PRP). Topics covered include the current regulatory environment, economic outlook, and current clinical evidence.

Recent Findings

The global PRP market is expected to grow to between 380 million and 4.5 billion (USD) over the next 5–10 years. The cost of a single treatment, which is not covered by most insurance, is roughly $500–$2500, with patients often returning for additional treatments.

Summary

While PRP is not ‘FDA-approved’, it can be legally offered in the clinic ‘off-label’ in the USA for a myriad of musculoskeletal indications. Recently published meta-analyses have demonstrated statistically significant improvements that, in some cases, suggest that PRP may have clinically meaningful effects. However, given the fact that clearance is not synonymous with approval, PRP is a costly treatment not covered by insurance, and clinical trials have not demonstrated definitive efficacy, we recommend informing patients when providing PRP ‘off-label’.

Keywords

HCT/Ps Platelet-rich plasma PRP Orthopedics Sports medicine Regenerative medicine 

Notes

Compliance with ethical standards

Conflict of Interest

Ian A. Jones and Ryan C. Togashi declare that they have no conflict of interests. C. Thomas Vangsness is a shareholder of CarthroniX.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Ian A. Jones
    • 1
  • Ryan C. Togashi
    • 1
  • C. Thomas VangsnessJr
    • 1
    Email author
  1. 1.Department of Orthopaedic SurgeryKeck School of Medicine of USCLos AngelesUSA

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