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Comparative modeling of retinol-binding protein-3 and retinal S-antigen in Eales’ disease and prediction of their binding sites using computational methods

  • Anshul Tiwari
  • Ashish Chandra Trivedi
  • Prachi Srivastava
  • Aditya Bhusan Pant
  • Sandeep Saxena
Article

Abstract

Retinal S-antigen and interphotoreceptor retinoid-binding protein-3 play a significant role in the etiopathogenesis of Eales' disease. Protein 3D structures are functionally very important and play a significant role in progression of the disease, hence these 3D structures are better target for further drug designing and relative studies. We developed 3D model structure of retinol-binding protein-3 and retinal S-antigen protein of human involved in Eales' disease. Functional site prediction is a very important and related step; hence, in the current course of analysis, we predicted putative functional site residues in the target proteins. Molecular models of these proteins of Eales' disease as documented in this study may provide a valuable aid for designing an inhibitor or better ligand against Eales' disease and could play a significant role in drug design.

Keywords

Eales' disease Retinol-binding protein-3 Retinal S-antigen Hemorrhages Venoocclusive Modeling Functional sites 

Notes

Acknowledgments

We wish to express our acknowledgement to Mr. Aseem Chauhan, Additional President, RBEF parent organization of Amity University Uttar Pradesh (AUUP) and chairman of Amity University Lucknow Campus; Maj. Gen. K.K Ohri, AVSM (Retd.), Director General of AUUP- Lucknow Campus, Asst. Professor Dr. Rajesh K. Tiwari, Deputy Director and Head, Amity Institute of Biotechnology, Lucknow and Professor Shally Awasthi, Dept. of Pediatrics, CSM Medical university, Lucknow, UP for providing their valuable support and encouragement throughout the work.

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Anshul Tiwari
    • 1
  • Ashish Chandra Trivedi
    • 3
  • Prachi Srivastava
    • 3
  • Aditya Bhusan Pant
    • 2
  • Sandeep Saxena
    • 1
  1. 1.Department of OphthalmologyCSM Medical University (Erstwhile King George’s Medical University)LucknowIndia
  2. 2.Indian Institute of Toxicological ResearchLucknowIndia
  3. 3.Amity Institute of BiotechnologyAmity University, Lucknow CampusLucknowIndia

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