Comparative modeling of retinol-binding protein-3 and retinal S-antigen in Eales’ disease and prediction of their binding sites using computational methods
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Retinal S-antigen and interphotoreceptor retinoid-binding protein-3 play a significant role in the etiopathogenesis of Eales' disease. Protein 3D structures are functionally very important and play a significant role in progression of the disease, hence these 3D structures are better target for further drug designing and relative studies. We developed 3D model structure of retinol-binding protein-3 and retinal S-antigen protein of human involved in Eales' disease. Functional site prediction is a very important and related step; hence, in the current course of analysis, we predicted putative functional site residues in the target proteins. Molecular models of these proteins of Eales' disease as documented in this study may provide a valuable aid for designing an inhibitor or better ligand against Eales' disease and could play a significant role in drug design.
KeywordsEales' disease Retinol-binding protein-3 Retinal S-antigen Hemorrhages Venoocclusive Modeling Functional sites
- 1.Sen A, Paine SK, Chowdhury IH, Mukherjee A, Choudhury S, Mandal LK, Bhattacharya B. Assessment of gelatinase and tumor necrosis factor-a level in the vitreous and serum of patients with Eales disease: Role of Inflammation-Mediated Angiogenesis in the Pathogenesis of Eales Disease .Retina. 2011. doi: 10.1097/IAE.0b013e318203c199.
- 2.Saxena S, Kumar D, Singh VK, Rajasingh J. Immunological studies in Eales disease: a review. Afro-Asian J Ophthalmol. 1995;13:19–22.Google Scholar
- 11.Gasteiger E, Hoogland C, Gattiker A, Duvaud S, Wilkins MR, Appel RD, Bairoch A. Protein identification and analysis tools on the ExPASy Server; John M. Walker, editors: The Proteomics Protocols Handbook, Humana. 2005. p. 571–607.Google Scholar
- 14.Peitsch MC. Protein modeling by e-mail bio/technology. Nature. 1995;13:658–60.Google Scholar
- 21.Srivastava P, Tiwari A, Trivedi AC. Computational prediction of 3D structure for the matrix protein 2 (BM2) of the influenza B virus. Intl Med Technol Univ Med J. 2010;1:22–36.Google Scholar