Comparative modeling of retinol-binding protein-3 and retinal S-antigen in Eales’ disease and prediction of their binding sites using computational methods

  • Anshul Tiwari
  • Ashish Chandra Trivedi
  • Prachi Srivastava
  • Aditya Bhusan Pant
  • Sandeep Saxena


Retinal S-antigen and interphotoreceptor retinoid-binding protein-3 play a significant role in the etiopathogenesis of Eales' disease. Protein 3D structures are functionally very important and play a significant role in progression of the disease, hence these 3D structures are better target for further drug designing and relative studies. We developed 3D model structure of retinol-binding protein-3 and retinal S-antigen protein of human involved in Eales' disease. Functional site prediction is a very important and related step; hence, in the current course of analysis, we predicted putative functional site residues in the target proteins. Molecular models of these proteins of Eales' disease as documented in this study may provide a valuable aid for designing an inhibitor or better ligand against Eales' disease and could play a significant role in drug design.


Eales' disease Retinol-binding protein-3 Retinal S-antigen Hemorrhages Venoocclusive Modeling Functional sites 


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Anshul Tiwari
    • 1
  • Ashish Chandra Trivedi
    • 3
  • Prachi Srivastava
    • 3
  • Aditya Bhusan Pant
    • 2
  • Sandeep Saxena
    • 1
  1. 1.Department of OphthalmologyCSM Medical University (Erstwhile King George’s Medical University)LucknowIndia
  2. 2.Indian Institute of Toxicological ResearchLucknowIndia
  3. 3.Amity Institute of BiotechnologyAmity University, Lucknow CampusLucknowIndia

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