The Unchartered Frontier: Preventive Cardiology Between the Ages of 15 and 35 Years

Pediatrics (S. Gooding, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Pediatrics


It is well established that atherosclerosis, the pathological basis of cardiovascular disease (CVD), begins in childhood and progresses steadily between the ages of 15 to 35 years. These adolescent and young adult years are also marked by significant physiological, psychological, and sociodemographic changes that impact both CVD risk factor development and CVD prevention and treatment strategies. In this review, we highlight the importance of the primordial prevention of CVD risk factors before they ever occur and the primary prevention of CVD by treating CVD risk factors in this age group. Although the long time to first CVD event for most young people precludes the availability of clinical trials with hard end-points, findings from epidemiology, health psychology, health services research, and clinical trials with surrogate end-points are discussed to inform an evidence-based approach to CVD prevention in adolescents and young adults.


Adolescents Young adults Primordial prevention Primary prevention Risk factors 


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.Departments of Medicine and Pediatrics at Harvard Medical School, Division of Adolescent/Young Adult Medicine at Boston Children’s Hospital, and Division of General Internal Medicine at Brigham and Women’s HospitalBostonUSA
  2. 2.Division of Cardiovascular MedicineUniversity of Wisconsin School of Medicine and Public HealthMadisonUSA

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