Sprue-like Enteropathy Associated with Olmesartan

  • Amanda K. Cartee
  • Joseph A. MurrayEmail author
Hypertension (S Taler, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Hypertension


Olmesartan-associated enteropathy (OAE) is a newly described condition reported in several case series in which patients taking olmesartan developed diarrhea, nausea, vomiting, dehydration, and weight loss. Although the symptoms and histologic findings of small-bowel enteropathy resembled severe celiac disease, laboratory work and the lack of response to a gluten-free diet challenged that diagnosis. The injury extended beyond the small bowel, with evidence of lymphocytic/collagenous gastritis and/or colitis in a substantial subset of patients. After a thorough diagnostic evaluation including consideration of alternate diagnoses, and resistance to a variety of treatments, a common thread became apparent: that all affected patients were taking olmesartan. Once this connection was recognized and the medication was suspended, symptoms would improve and the enteropathy healed. Some patients required corticosteroids particularly budesonide (a topically potent steroid) to achieve remission. There remains a gap in knowledge regarding the predisposing factors and mechanism of action.


Olmesartan Diarrhea Enteropathy 


Compliance with Ethics Guidelines

Conflict of Interest

Joseph Murray and Amanda Cartee have no disclosures relevant to this work.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Division of Gastroenterology and HepatologyMayo ClinicRochesterUSA

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