Current Cardiovascular Risk Reports

, Volume 7, Issue 6, pp 490–494 | Cite as

Diabetic Cardiomyopathy in the Elderly

Elderly and Heart Disease (J Wei and G Azhar, Section Editors)
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Abstract

Diabetic cardiomyopathy is a microvascular disorder that occurs in diabetics that may lead to congestive heart failure (CHF) in the absence of hypertension, coronary artery disease, or valvular heart disease. In a large study of elderly subjects with 865 men and 1872 women, mean age 81 ± 9 years, CHF developed in 272 of 690 diabetics (39 %) and in 467 of 2047 nondiabetics (23 %) (P < 0.0001) at 43-month follow-up. Cox regression analysis showed that diabetes mellitus (risk ratio = 1.34, P = 0.0003) was an independent significant predictor of time to development of CHF. For each 1 % increase in hemoglobin A1c, in 25,958 men and 22,900 women with diabetes, there was an 8 % increased risk of CHF (95 % CI, 5 %–12 %). The pathologic substrate of diabetic cardiomyopathy is characterized by myocardial damage, left ventricular hypertrophy, interstitial fibrosis, structural and functional changes of the coronary vessels, metabolic abnormalities, and autonomic cardiac neuropathy.

Keywords

Diabetic cardiomyopathy Heart failure Hyperglycemia Dyslipidemia Left ventricular hypertrophy Ejection fraction Diastolic dysfunction 

Notes

Compliance with Ethics Guidelines

Conflict of Interest

Wilbert S. Aronow declares that he has no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Medicine, Divisions of Cardiology, Geriatrics, and Pulmonary/Critical CareNew York Medical CollegeValhallaUSA

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