Current Cardiovascular Risk Reports

, Volume 7, Issue 5, pp 401–408 | Cite as

Novel Approaches for the Treatment of the Patient with Resistant Hypertension: Renal Nerve Ablation

Secondary Prevention and Intervention (J Foody, Section Editor)


Sympathetic innervation of the kidneys plays a major role in the pathogenesis of hypertension through modulation of renin secretion, glomerular filtration rate and renal absorption of sodium. Targeted interventions for renal nerve ablation are being developed for treatment of drug-resistant hypertension in the USA and the rest of the world. Early studies with the use of radiofrequency-based renal denervation systems have shown encouraging results with significant reduction of blood pressure in patients inadequately controlled despite nearly maximal drug therapy regimens. Thus far, the renal denervation procedure has been associated with minimal side effects. Long-term efficacy and safety beyond 3 years needs to be determined for renal nerve ablation. This review focuses on the physiology of the renal sympathetic system, the rationale for renal nerve ablation and current evidence in support of the available therapeutic renal denervation systems.


Resistant hypertension Renal denervation Renal nerve ablation Sympathetic nervous system 


Compliance with Ethics Guidelines

Conflict of Interest

Vinay Gulati declares that he has no conflict of interest.

William B. White is a steering committee member for St. Jude Medical.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Division of Hypertension and Clinical Pharmacology, Calhoun Cardiology CenterUniversity of Connecticut Health Center, University of Connecticut School of MedicineFarmingtonUSA

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