Rapid Food Product Analysis by Surface Acoustic Wave Nebulization Coupled Mass Spectrometry
Rapid food product analysis is of great interest for quality control and assurance during the production process. Conventional quality control protocols require time and labor-intensive sample preparation for analysis by state-of-the-art analytical methods. To reduce overall cost and facilitate rapid qualitative assessments, food products need to be tested with minimal sample preparation. We present a novel and simple method for assessing food product compositions by mass spectrometry using a novel surface acoustic wave nebulization method. This method provides significant advantages over conventional methods requiring no pumps, capillaries, or additional chemicals to enhance ionization for mass spectrometric analysis. In addition, the surface acoustic wave nebulization–mass spectrometry method is ideal for rapid analysis and to investigate certain compounds by using the mass spectra as a type of species-specific fingerprint analysis. We present for the first time surface acoustic wave nebulization-generated mass spectra of a variety of fermented food products from a small selection of vinegars, wines, and beers.
KeywordsMass spectrometry Surface acoustic wave nebulization Vinegar, wine, and beer analysis
Compliance with Ethical Standards
Conflict of Interest
Thomas Schneider declares that he has no conflict of interest. David P. A. Kilgour declares that he has no conflict of interest. Erik Nilsson declares that he has no conflict of interest. David R. Goodlett has financial interests in Deurion LLC.
This article does not contain any studies with human participants or animals performed by any of the authors.
- Belitz HD, Grosch W, Schieberle P (2009) Food chemistry, 4th edn. Springer-Verlag, BerlinGoogle Scholar
- Bravdo B, Hepner Y, Loinger C et al (1985) Effect of crop level and crop load on growth, yield, must and wine composition, and quality of cabernet sauvignon. Am J Enol Vitic 36:125–131Google Scholar
- Coats SR, Jones JW, Do CT, Braham PH, Bainbridge BW, To TT, Goodlett DR, Ernst RK, Darveau RP (2009) Human Toll-like receptor 4 responses to P. gingivalis are regulated by lipid A 1- and 4’-phosphatase activities. Cell Microbiol 11:1587–1599. https://doi.org/10.1111/j.1462-5822.2009.01349.x CrossRefGoogle Scholar
- Flamini R, Traldi P (2010) Mass spectrometry in grape and wine chemistry. John Wiley & Sons, Inc., HobokenGoogle Scholar
- Frangne N, Eggmann T, Koblischke C, Weissenbock G, Martinoia E, Klein M (2002) Flavone glucoside uptake into barley mesophyll and Arabidopsis cell culture vacuoles. Energization occurs by H(+)-antiport and ATP-binding cassette-type mechanisms. Plant Physiol 128:726–733. https://doi.org/10.1104/pp.010590 CrossRefGoogle Scholar
- García-Villalba R, Cortacero-Ramírez S, Segura-Carretero A, Martín-Lagos Contreras JA, Fernández-Gutiérrez A (2006) Analysis of hop acids and their oxidized derivatives and iso-α-acids in beer by capillary electrophoresis−electrospray ionization mass spectrometry. J Agric Food Chem 54:5400–5409. https://doi.org/10.1021/jf060207x CrossRefGoogle Scholar
- Liang T, Schneider T, Yoon SH, et al (2017) Optimized surface acoustic wave nebulization facilitates bacterial phenotypingGoogle Scholar
- Nicholson JR (2017) 2015: what is made in America. Economics and Statistics Administration (ESA), http://www.esa.doc.gov/reports/2015-what-made-america. Accessed 24 Sept 2017
- Nordhoff E, Kirpekar F, Roepstorff P (1996) Mass spectrometry of nucleic acids. Mass Spectrom Rev 15:67–138. https://doi.org/10.1002/(sici)1098-2787(1996)15:2<67::aid-mas1>3.0.co;2-8 CrossRefGoogle Scholar
- Ough C (1968) Proline content of grapes and wines. Vitis 7:321–331Google Scholar
- Peppard TL (1985) The application of mass spectrometry in beer flavour studies. J Inst Brew 91:16–24. https://doi.org/10.1002/j.2050-0416.1985.tb04299.x CrossRefGoogle Scholar
- Quifer-Rada P, Vallverdú-Queralt A, Martínez-Huélamo M, Chiva-Blanch G, Jáuregui O, Estruch R, Lamuela-Raventós R (2015) A comprehensive characterisation of beer polyphenols by high resolution mass spectrometry (LC-ESI-LTQ-Orbitrap-MS). Food Chem 169:336–343. https://doi.org/10.1016/j.foodchem.2014.07.154 CrossRefGoogle Scholar
- Yeo LY, Friend JR (2014) Surface acoustic wave microfluidics. Annu Rev Fluid Mech 46:379–406. https://doi.org/10.1146/annurev-fluid-010313-141418 CrossRefGoogle Scholar
- Yoon SH, Liang T, Schneider T, Oyler BL, Chandler CE, Ernst RK, Yen GS, Huang Y, Nilsson E, Goodlett DR (2016) Rapid lipid a structure determination via surface acoustic wave nebulization and hierarchical tandem mass spectrometry algorithm. Rapid Commun Mass Spectrom 30:2555–2560CrossRefGoogle Scholar
- Zhang J, Rector J, Lin JQ, Young JH, Sans M, Katta N, Giese N, Yu W, Nagi C, Suliburk J, Liu J, Bensussan A, DeHoog RJ, Garza KY, Ludolph B, Sorace AG, Syed A, Zahedivash A, Milner TE, Eberlin LS (2017) Nondestructive tissue analysis for ex vivo and in vivo cancer diagnosis using a handheld mass spectrometry system. Sci Transl Med. https://doi.org/10.1126/scitranslmed.aan3968 Google Scholar