Food Analytical Methods

, Volume 7, Issue 1, pp 100–108 | Cite as

Magnetic Mixed Hemimicelles Solid-Phase Extraction of Three Food Colorants from Real Samples

  • Mehdi Tavakoli
  • Farzaneh Shemirani
  • Mannan HajimahmoodiEmail author


Introducing a specific clean extraction procedure with a minimal matrices effect for food colorant determination is still a challengeable topic and highly recommended. Mixed hemimicelle solid-phase extraction method, based on cetyltrimethylammonium bromide-coated Fe3O4/SiO2 nanoparticles as a novel, simple, and fast preconcentration method, was applied for preconcentration and fast isolation of three synthetic food colorants in foodstuff matrices prior to HPLC-UV-vis determination. The influence of different parameters on extraction efficiency such as surfactant amount, sample pH, time of extraction, desorption condition, and nanoparticles concentration was optimized. Under the optimized conditions, a preconcentration factor of 100 was achieved by extracting 10 mL sample. The limit of detection for the three synthetic food colorants including Tartrazine, Sunset yellow FCF, and Quinoline yellow is 2.50, 1.25, and 2.12 μg/L, respectively. The proposed method was applicable for extraction and preconcentration of three food colorants in various food samples with the food dye contents in the range of 13–105 μg/L.


Food colorant Mixed hemimicelles Solid-phase extraction Silica-coated magnetic nanoparticles HPLC 



The support by the Research Council of University of Tehran, along with Tehran University of Medical Sciences and Health Services through a Grant to conduct this study is gratefully acknowledged.

Conflict of Interest

The authors declare that they have no conflict of interest. The article does not contain any studies with human or animal subjects and the authors do not have a financial relationship with the organization that sponsored the research. The financial support came from the Research Council of the University of Tehran, which does not have commercial interest.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Mehdi Tavakoli
    • 1
  • Farzaneh Shemirani
    • 1
  • Mannan Hajimahmoodi
    • 2
    • 3
    Email author
  1. 1.Department of Chemistry, Faculty of ScienceUniversity of TehranTehranIran
  2. 2.Drug and Food Control Department, Faculty of PharmacyTehran University of Medical SciencesTehranIran
  3. 3.Traditional Persian Medicine and Pharmacy Research CenterTehran University of Medical SciencesTehranIran

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