Annals of Behavioral Medicine

, Volume 51, Issue 4, pp 620–628 | Cite as

Accumulation of Depressive Symptoms and Carotid Intima-Media Thickness: the Cardiovascular Risk in Young Finns Study

  • Liisa Keltikangas-Järvinen
  • Kateryna Savelieva
  • Kim Josefsson
  • Marko Elovainio
  • Laura Pulkki-Råback
  • Markus Juonala
  • Olli T. Raitakari
  • Mirka Hintsanen
Original Article

Abstract

Background

The association between depressive symptoms and subclinical atherosclerosis has been inconsistent.

Purpose

We sought to replicate our previous study, which demonstrated a positive relation between depressive symptoms and subclinical atherosclerosis assessed with carotid intima-media thickness (IMT) in men, using a newer measurement of carotid IMT and a cumulative loading of depressive symptoms over three follow-ups.

Methods

The sample comprised 996 adults (352 men) aged 30 to 45 years in 2007 from a prospective population-based Finnish sample. The participants completed a modified version of Beck Depression Inventory in 1992, 1997, and 2001. Carotid IMT was assessed with ultrasound in 2001 and 2007. Cardiovascular risk factors (i.e., body mass index, systolic blood pressure, low-density lipoprotein cholesterol, and smoking) were measured in childhood (1980) and in adulthood (2007).

Results

We found no association between the accumulative depression index and carotid IMT before or after controlling for the traditional risk factors (all p values ≥0.67). Depressive symptoms did not predict IMT progression over two time points and the highest level of carotid wall thickening. Imputed and non-imputed data sets provided similar results. Results remained the same when men and women were analyzed separately. Additional analyses revealed no significant interactions between depressive symptoms and cardiovascular risk factors (i.e., body mass index and systolic blood pressure) on carotid IMT (all p values >0.15).

Conclusions

The findings of this population-based study did not indicate any direct association between depressive symptoms and carotid IMT in asymptomatic, young adults.

Keywords

Atherosclerosis Carotid intima-media thickness Depression Psychosomatic 

Supplementary material

12160_2017_9884_MOESM1_ESM.docx (37 kb)
ESM 1(DOCX 37.2 kb)

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Copyright information

© The Society of Behavioral Medicine 2017

Authors and Affiliations

  • Liisa Keltikangas-Järvinen
    • 1
  • Kateryna Savelieva
    • 1
  • Kim Josefsson
    • 2
  • Marko Elovainio
    • 1
    • 2
  • Laura Pulkki-Råback
    • 3
    • 1
  • Markus Juonala
    • 4
    • 5
    • 6
  • Olli T. Raitakari
    • 7
    • 8
  • Mirka Hintsanen
    • 1
    • 9
  1. 1.Institute of Behavioural SciencesUniversity of HelsinkiHelsinkiFinland
  2. 2.National Institute for Health and WelfareHelsinkiFinland
  3. 3.Helsinki Collegium for Advanced StudiesUniversity of HelsinkiHelsinkiFinland
  4. 4.Department of MedicineUniversity of TurkuTurkuFinland
  5. 5.Division of MedicineTurku University HospitalTurkuFinland
  6. 6.Murdoch Childrens Research InstituteParkvilleAustralia
  7. 7.Research Centre of Applied and Preventive Cardiovascular MedicineUniversity of TurkuTurkuFinland
  8. 8.Department of Clinical Physiology and Nuclear MedicineTurku University HospitalTurkuFinland
  9. 9.Unit of Psychology, Faculty of EducationUniversity of OuluOuluFinland

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