Annals of Behavioral Medicine

, Volume 46, Issue 2, pp 149–156 | Cite as

Physical Activity and Health Outcomes Among HIV-Infected Men Who Have Sex with Men: A Longitudinal Mediational Analysis

  • Aaron J. Blashill
  • Kenneth H. Mayer
  • Heidi Crane
  • Jessica F. Magidson
  • Chris Grasso
  • W. Christopher Mathews
  • Michael S. Saag
  • Steven A. Safren
Original Article



Low physical activity is associated with depression, which may, in turn, negatively impact antiretroviral therapy (ART) adherence among HIV-infected individuals; however, prior studies have not investigated the relationships between physical inactivity and ART non-adherence.


The purpose of this study was to examine the association of physical inactivity, depression, ART non-adherence, and viral load in HIV-infected men who have sex with men.


The sample (N = 860) was from a large, multicenter cohort of HIV-infected patients engaged in clinical care.


Across time, depression mediated the relationship between physical inactivity and ART non-adherence (γ = 0.075) and the relationship between physical inactivity and viral load (γ = 0.05). ART non-adherence mediated the relationship between depression and viral load (γ = 0.002) and the relationship between physical inactivity and viral load (γ = 0.009).


Low levels of physical activity predicted increased depression and poor ART adherence over time, which subsequently predicted higher viral load.


HIV/AIDS Physical activity Depression Adherence Viral load 


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Copyright information

© The Society of Behavioral Medicine 2013

Authors and Affiliations

  • Aaron J. Blashill
    • 1
    • 2
    • 3
    • 8
  • Kenneth H. Mayer
    • 2
    • 3
    • 4
  • Heidi Crane
    • 5
  • Jessica F. Magidson
    • 1
    • 2
  • Chris Grasso
    • 3
  • W. Christopher Mathews
    • 6
  • Michael S. Saag
    • 7
  • Steven A. Safren
    • 1
    • 2
    • 3
  1. 1.Massachusetts General HospitalBostonUSA
  2. 2.Harvard Medical SchoolBostonUSA
  3. 3.The Fenway InstituteBostonUSA
  4. 4.Beth Israel Deaconess Medical CenterBostonUSA
  5. 5.University of WashingtonSeattleUSA
  6. 6.University of California San Diego Medical CenterSan DiegoUSA
  7. 7.University of Alabama BirminghamBirminghamUSA
  8. 8.BostonUSA

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