Treatment-Related Optimism Protects Quality of Life in a Phase II Clinical Trial for Metastatic Renal Cell Carcinoma
- First Online:
Patients on clinical trials often experience declining quality of life (QOL). Little is known about the psychosocial variables that buffer against decline.
This study aims to examine correlations between psychosocial variables and QOL over the course of a clinical trial in patients with metastatic renal cell cancer.
At baseline, 114 participants completed measures of treatment-related optimism, social support, and QOL (Functional Assessment of Cancer Therapy-General). QOL was also assessed 2, 4, and 8 weeks after the start of treatment with low-dose or intermediate-dose interferon.
QOL decreased significantly in the intermediate-dose group but not in the low-dose group (p < .01). The decline was less severe for patients who had high rather than low treatment optimism (p = .03). A higher level of social support was significantly associated with higher baseline QOL (p < .05) but a more rapid decline in QOL over time (p < .01).
Treatment optimism was favorably associated with QOL.
KeywordsTreatment-related optimism Social support Metastatic renal cell cancer Clinical trial
- 19.Rosen NO, Knäuper B, DiDio P, Morrison E, Tabing R, Feldstain A, Amsel R, Mayrand MH, Franco EL, Rosberger Z: The impact of intolerance of uncertainty on anxiety after receiving an informational intervention about HPV: A randomised controlled study. Psychol Health. 2010, 25:651–668.PubMedCrossRefGoogle Scholar
- 29.Kenn DA KD, Cook WL: Dyadic data analysis. New York: Guilford Press, 2006.Google Scholar
- 30.Wolfer R, Sang C: Comparing the SAS GLM and MIXED procedures for repeated measures. In: Proceedings of the Twentieth Annual SAS Users Group Conference, Cary, NC. Cary, NC: 1995.Google Scholar
- 31.Snijders T, Bosker R: Multilevel analysis. Thousand Oaks: Sage, 1999.Google Scholar
- 34.Thoits PA: Stress, coping, and social support process: Where are we? What next? Journal of Health and Social Behavior. 1995, 35:Extra issue: Forty years of medical sociology: The state of the art and directions for the future.Google Scholar