Oncology Reviews

, Volume 3, Issue 1, pp 3–18

An insight into tumoral hypoxia: the radiomarkers and clinical applications

  • Ana Margarida Abrantes
  • Maria Elisa Serra
  • Dina Murtinho
  • António Rocha Gonsalves
  • Maria Filomena Botelho
Review

DOI: 10.1007/s12156-009-0001-z

Cite this article as:
Abrantes, A.M., Serra, M.E., Murtinho, D. et al. Oncol Rev (2009) 3: 3. doi:10.1007/s12156-009-0001-z

Abstract

Tumoral hypoxia is related to severe structural abnormalities of tumor microvessels, leading to deteriorated O2 diffusion. This decreased O2 concentration in cancer cells compromises cellular functions, besides being responsible for resistance to radiation therapy. Consequently, it is very important to know the hypoxic status of a tumor. In this review, the different methodologies available for evaluating cellular hypoxia in vivo are discussed, particularly those in which the hypoxia information is obtained through imaging. Among these the nuclear medicine approach uses ligands to complex with radionuclides. The resulting radioactive complexes which may be single photon or positron emitters, are very useful as imaging probes. The nature of ligands and their corresponding complexes, with application or potential application as hypoxia detectors, will be described. A summary of the most significant results so far obtained in clinical or pre-clinical applications will also be discussed.

Keywords

Tumoral hypoxia Functional imaging Radiomarkers Nuclear medicine 

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Ana Margarida Abrantes
    • 1
    • 2
  • Maria Elisa Serra
    • 3
  • Dina Murtinho
    • 3
  • António Rocha Gonsalves
    • 3
  • Maria Filomena Botelho
    • 1
    • 2
  1. 1.Biophysics/Biomathematics Institute, IBILI, Faculty of MedicineUniversity of CoimbraCoimbraPortugal
  2. 2.Faculty of MedicineOncology, Genetics and Environment Research Center, CIMAGOCoimbraPortugal
  3. 3.Chemistry Department, Faculty of Sciences and TechnologyUniversity of CoimbraCoimbraPortugal

Personalised recommendations