Journal of Chemical Biology

, Volume 4, Issue 3, pp 109–116

Hill coefficients of dietary polyphenolic enzyme inhibitiors: can beneficial health effects of dietary polyphenols be explained by allosteric enzyme denaturing?

  • Nikolai Kuhnert
  • Farnoosh Dairpoosh
  • Rakesh Jaiswal
  • Marius Matei
  • Sagar Deshpande
  • Agnieszka Golon
  • Hany Nour
  • Hande Karaköse
  • Nadim Hourani
Original Article

Abstract

Inspired by a recent article by Prinz, suggesting that Hill coefficients, obtained from four parameter logistic fits to dose–response curves, represent a parameter allowing distinction between a general allosteric denaturing process and real single site enzyme inhibition, Hill coefficients of a number of selected dietary polyphenol enzyme inhibitions were compiled from the available literature. From available literature data, it is apparent that the majority of polyphenol enzyme interactions reported lead to enzyme inhibition via allosteric denaturing rather than single site inhibition as judged by their reported Hill coefficients. The results of these searches are presented and their implications discussed leading to the suggestion of a novel hypothesis for polyphenol biological activity termed the insect swarm hypothesis.

Keywords

Polyphenols Enzyme inhibition Human diet 

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Nikolai Kuhnert
    • 1
  • Farnoosh Dairpoosh
    • 1
  • Rakesh Jaiswal
    • 1
  • Marius Matei
    • 1
  • Sagar Deshpande
    • 1
  • Agnieszka Golon
    • 1
  • Hany Nour
    • 1
  • Hande Karaköse
    • 1
  • Nadim Hourani
    • 1
  1. 1.School of Engineering and Science, Centre for Nano- and functional materialsJacobs University BremenBremenGermany

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