Annals of Nuclear Medicine

, Volume 33, Issue 12, pp 945–954 | Cite as

Evaluation of PSMA expression changes on PET/CT before and after initiation of novel antiandrogen drugs (enzalutamide or abiraterone) in metastatic castration-resistant prostate cancer patients

  • Nicolas PlouznikoffEmail author
  • Carlos Artigas
  • Spyridon Sideris
  • Nieves Martinez Chanza
  • Thierry Gil
  • Alexandre Peltier
  • Patrick Flamen
Short Communication



To investigate the association between Prostate-Specific Membrane Antigen (PSMA) expression changes on positron emission tomography–computed tomography (PET/CT) and the response to treatment following the start of enzalutamide or abiraterone in metastatic castration-resistant prostate cancer (mCRPC) patients.


All consecutive 68Ga-PSMA-11 PET/CT scans routinely performed at our institution during more than 4 years were retrospectively screened for inclusion. We included mCRPC patients with a baseline PSMA PET/CT performed less than 2 months before the start of either enzalutamide or abiraterone, and a follow-up PSMA PET/CT performed no more than a year after, while still under those novel antiandrogen drugs (NAD). The associated clinical records were reviewed. Patients were considered treatment responders if they presented decreasing PSA levels > 50% or a radiological response based on RECIST 1.1 criteria. PSMA expression changes on the follow-up PET/CT were assessed using per-patient dominant response criteria to classify patients as PSMA-responders (complete disappearance of pathologic PSMA uptake, or a decreased uptake of the majority of lesions) or PSMA-non-responders (new PSMA-expressing lesions, increased uptake of the majority of lesions, or stable PSMA expression of the disease). Descriptive statistics and measures of associations (two-sided Fisher’s exact test and Phi coefficient) were calculated.


A total of 11 and 15 patients were included in the enzalutamide and abiraterone groups. Median follow-up was 110 (IQR 76–124) and 87 (IQR 71–242) days, respectively. All treatment responders (3 enzalutamide and 4 abiraterone) were considered PSMA-responders, and all treatment non-responders (8 enzalutamide, 11 abiraterone) were considered PSMA-non-responders. PSMA PET response was thus perfectly associated with conventional response criteria (p = 0.006, Phi = 1 for enzalutamide; p = 0.001, Phi = 1 for abiraterone). In our cohort, no PSMA expression flare phenomenon was detected on follow-up PET/CT scans at a median follow-up of 3 months. However, an early and short-lived flare cannot be excluded.


This retrospective study suggests that, after a median follow-up of 3 months under enzalutamide or abiraterone, PSMA expression changes on PET/CT are strongly associated with response to treatment. Prospective studies are needed to better understand PSMA expression dynamics following the start of enzalutamide and abiraterone, along with the role of PSMA PET/CT in response assessment.


PSMA Response Enzalutamide Abiraterone mCRPC 


Author contributions

Dr. NP performed the data collection, the data analysis, and drafted the manuscript; Dr. CA designed the study, reviewed the data and revised the manuscript; Dr. SS, Dr. NMC, Dr. TG and Dr. AP clinically followed the patients and reviewed the manuscript; Dr. PF revised the manuscript for important intellectual content.


N. P. is a recipient of a Detweiler Travelling Fellowship provided by the Royal College of Physicians and Surgeons of Canada.

Compliance with ethical standards

Conflict of interest

No conflict of interest to declare for any author.

Ethics approval

This study was performed in accordance with our institution ethical standards, as well as with the standards laid down in the 1964 Declaration of Helsinki and its subsequent revisions or equivalent ethical standards.

Informed consent

Due to the retrospective, descriptive and aggregate nature of the study, no specific patient consent was deemed necessary by our institutional ethics review board.


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Copyright information

© The Japanese Society of Nuclear Medicine 2019

Authors and Affiliations

  1. 1.Department of Nuclear Medicine, Institut Jules BordetUniversité Libre de Bruxelles (ULB)BrusselsBelgium
  2. 2.Department of Nuclear MedicineCentre Hospitalier de l’Université de Montréal (CHUM)MontrealCanada
  3. 3.Department of Oncology, Institut Jules BordetUniversité Libre de Bruxelles (ULB)BrusselsBelgium
  4. 4.Department of Urology, Institut Jules BordetUniversité Libre de Bruxelles (ULB)BrusselsBelgium

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