Annals of Nuclear Medicine

, Volume 33, Issue 1, pp 1–13 | Cite as

Techniques for generating attenuation map using cardiac SPECT emission data only: a systematic review

  • Getu Ferenji Tadesse
  • Parham Geramifar
  • Eyachew Misganew Tegaw
  • Mohammad Reza AyEmail author
Review Article


To reliably interpret and perform quantitative analysis, attenuation correction for cardiac single-photon emission computed tomography (SPECT) is fundamental. Thus, knowledge of the patient-specific attenuation map for accurate correction is required in SPECT quantitative imaging. The aim of this systematic review is to present general principles of attenuation correction and provide a structured summary of the approaches that have been proposed for generating the attenuation map for cardiac SPECT. We identified relevant articles published in English pertaining to the attenuation map (AM) determination using SPECT emission data only by searching PubMed, EMBASE, Scopus, and Web of Science databases. Moreover, other articles were hand searched. The protocol of this systematic review was registered in PROSPERO and the code given is CRD42017060512. Transmissionless techniques of determining attenuation map including calculated methods, statistical modeling for simultaneous estimation of attenuation and emission, consistency conditions criteria, using scattered data and other methods were reviewed. Methods for performing attenuation map for cardiac SPECT are developing and the progresses made are promising. However, much work is needed to assess the efficacy of the correction schemes in the clinical routine.


Attenuation correction Attenuation map Cardiac SPECT Emission data 



This work was supported under grant number 38086, International campus, Tehran University of Medical Sciences, Tehran, Iran.

Conflict of interest

The authors declare that there is no conflict of interest.


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Copyright information

© The Japanese Society of Nuclear Medicine 2018

Authors and Affiliations

  1. 1.Department of Medical Physics and Biomedical engineering, School of MedicineTehran University of Medical SciencesTehranIran
  2. 2.Department of Medical Physics and Biomedical engineering, School of MedicineTehran University of Medical Sciences, International campusTehranIran
  3. 3.Department of Physics, College of Natural SciencesAksum UniversityAxumEthiopia
  4. 4.Research Center for Nuclear Medicine, Shariati HospitalTehran University of Medical SciencesTehranIran
  5. 5.Department of Physics, College of Natural SciencesDebre Tabor UniversityDebre TaborEthiopia
  6. 6.Research Center for Molecular and Cellular ImagingTehran University of Medical SciencesTehranIran

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