Annals of Nuclear Medicine

, Volume 32, Issue 5, pp 319–327 | Cite as

Diagnostic value of quantitative assessment of cardiac 18F-fluoro-2-deoxyglucose uptake in suspected cardiac sarcoidosis

  • Adrien Lebasnier
  • Damien Legallois
  • Boris Bienvenu
  • Emmanuel Bergot
  • Cédric Desmonts
  • Gérard Zalcman
  • Denis Agostini
  • Alain ManriqueEmail author
Original Article



The identification of cardiac sarcoidosis is challenging as there is no gold standard consensually admitted for its diagnosis. The aim of this study was to evaluate the diagnostic value of the assessment of cardiac dynamic 18F-fluoro-2-deoxyglucose positron emission tomography (18F-FDG PET/CT) and net influx constant (Ki) in patients suspected of cardiac sarcoidosis.


Data obtained from 30 biopsy-proven sarcoidosis patients suspected of cardiac sarcoidosis who underwent a 50-min list-mode cardiac dynamic 18F-FDG PET/CT after a 24 h high-fat and low-carbohydrate diet were analyzed. A normalized coefficient of variation of quantitative glucose influx constant, calculated as the ratio: standard deviation of the segmental Ki (min−1)/global Ki (min−1) was determined using a validated software (Carimas® 2.4, Turku PET Centre). Cardiac sarcoidosis was diagnosed according to the Japanese Ministry of Health and Welfare criteria. Receiving operating curve analysis was performed to determine sensitivity and specificity of cardiac dynamic 18F-FDG PET/CT analysis to diagnose cardiac sarcoidosis.


Six out of 30 patients (20%) were diagnosed as having cardiac sarcoidosis. Myocardial glucose metabolism was significantly heterogeneous in patients with cardiac sarcoidosis who showed significantly higher normalized coefficient of variation values compared to patients without cardiac sarcoidosis (0.513 ± 0.175 vs. 0.205 ± 0.081; p = 0.0007). Using ROC curve analysis, we found a cut-off value of 0.38 for the diagnosis of cardiac sarcoidosis with a sensitivity of 100% and a specificity of 91%.


Our results suggest that quantitative analysis of cardiac dynamic 18F-FDG PET/CT could be a useful tool for the diagnosis of cardiac sarcoidosis.


Cardiac sarcoidosis Positron emission tomography Dynamic acquisition FDG Quantitative analysis 



Angiotensin-converting enzyme


C-reactive protein


Cardiac sarcoidosis


Computed tomography


Free fatty acids




Cardiac dynamic 18F-fluoro-2-deoxyglucose positron emission tomography


Full width at half maximum


High-fat and low-carbohydrate


Net influx constant


Myocardial perfusion imaging


Normalized coefficient of variation


Positron emission tomography


Receiving operating curve


Region of interest


Standard uptake value



This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.


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Copyright information

© The Japanese Society of Nuclear Medicine 2018

Authors and Affiliations

  1. 1.Department of Nuclear MedicineCHU de CaenCaenFrance
  2. 2.Normandie Université, UNICAEN, EA4650 Signalisation, Électrophysiologie et Imagerie des Lésions d’Ischémie-Reperfusion MyocardiqueCaenFrance
  3. 3.Department of CardiologyCHU de CaenCaenFrance
  4. 4.Department of Internal MedicineCHU de CaenCaenFrance
  5. 5.Department of Pulmonary MedicineCHU de CaenCaenFrance
  6. 6.Cyceron PET CentreCaenFrance

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