Annals of Nuclear Medicine

, Volume 31, Issue 6, pp 454–461 | Cite as

IQ-SPECT for thallium-201 myocardial perfusion imaging: effect of normal databases on quantification

  • Takahiro Konishi
  • Kenichi Nakajima
  • Koichi Okuda
  • Hiroto Yoneyama
  • Shinro Matsuo
  • Takayuki Shibutani
  • Masahisa Onoguchi
  • Seigo Kinuya
Original Article
First Online:
Received:
Accepted:

Abstract

Objective

Although IQ-single-photon emission computed tomography (SPECT) provides rapid acquisition and attenuation-corrected images, the unique technology may create characteristic distribution different from the conventional imaging. This study aimed to compare the diagnostic performance of IQ-SPECT using Japanese normal databases (NDBs) with that of the conventional SPECT for thallium-201 (201Tl) myocardial perfusion imaging (MPI).

Methods

A total of 36 patients underwent 1-day 201Tl adenosine stress–rest MPI. Images were acquired with IQ-SPECT at approximately one-quarter of the standard time of conventional SPECT. Projection data acquired with the IQ-SPECT system were reconstructed via an ordered subset conjugate gradient minimizer method with or without scatter and attenuation correction (SCAC). Projection data obtained using the conventional SPECT were reconstructed via a filtered back projection method without SCAC. The summed stress score (SSS) was calculated using NDBs created by the Japanese Society of Nuclear Medicine working group, and scores were compared between IQ-SPECT and conventional SPECT using the acquisition condition-matched NDBs. The diagnostic performance of the methods for the detection of coronary artery disease was also compared.

Results

SSSs were 6.6 ± 8.2 for the conventional SPECT, 6.6 ± 9.4 for IQ-SPECT without SCAC, and 6.5 ± 9.7 for IQ-SPECT with SCAC (p = n.s. for each comparison). The SSS showed a strong positive correlation between conventional SPECT and IQ-SPECT (r = 0.921 and p < 0.0001), and the correlation between IQ-SPECT with and without SCAC was also good (r = 0.907 and p < 0.0001). Regarding diagnostic performance, the sensitivity, specificity, and accuracy were 80.8, 78.9, and 79.4%, respectively, for the conventional SPECT; 80.8, 80.3, and 82.0%, respectively, for IQ-SPECT without SCAC; and 88.5, 86.8, and 87.3%, respectively, for IQ-SPECT with SCAC, respectively. The area under the curve obtained via receiver operating characteristic analysis were 0.77, 0.80, and 0.86 for conventional SPECT, IQ-SPECT without SCAC, and IQ-SPECT with SCAC, respectively (p = n.s. for each comparison).

Conclusions

When appropriate NDBs were used, the diagnostic performance of 201Tl IQ-SPECT was comparable with that of the conventional system regardless of different characteristics of myocardial accumulation in the conventional system.

Keywords

IQ-SPECT Japanese normal databases Myocardial perfusion imaging Rapid acquisition 
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Notes

Acknowledgements

We thank nuclear medicine technologists: Minoru Tobisaka, Masaaki Kawamura, Shuhei Minami, and Ayano Hosoki (Kanazawa University Hospital, Kanazawa, Japan) for their technological support. We also thank Takeshi Shimizu (Siemens Healthcare K.K., Tokyo, Japan) for his assistance. We would also like to thank enago (http://www.enago.jp) for English language editing.

Compliance with ethical standards

Conflict of interest

K. Nakajima has a collaborative research work with Siemens Healthcare K.K., Tokyo, Japan.

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Copyright information

© The Japanese Society of Nuclear Medicine 2017

Authors and Affiliations

  1. 1.Department of RadiologyKanazawa University HospitalKanazawaJapan
  2. 2.Department of Nuclear MedicineKanazawa University HospitalKanazawaJapan
  3. 3.Department of PhysicsKanazawa Medical UniversityKahokuJapan
  4. 4.Department of Quantum Medical Technology, Institute of Medical, Pharmaceutical and Health SciencesKanazawa UniversityKanazawaJapan

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