Annals of Nuclear Medicine

, Volume 31, Issue 3, pp 235–244 | Cite as

Influence of acquisition orbit on phase analysis of gated single photon emission computed tomography myocardial perfusion imaging for assessment of left ventricular mechanical dyssynchrony

  • Tomofumi Misaka
  • Makoto Hosono
  • Takashi Kudo
  • Takamichi Ito
  • Tsutomu Syomura
  • Masanobu Uemura
  • Kaoru Okajima
Original Article



The association between left ventricular (LV) dyssynchrony parameters, given by phase analysis of gated single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI), and acquisition orbits is unclear. The aim of this study was to assess the dependence of LV dyssynchrony parameters on acquisition orbits.


Ninety-nine patients who underwent 201Tl-gated SPECT MPI were categorized into minor hypoperfusion or major hypoperfusion groups. Forty-four patients who underwent 99mTc-tetrofosmin-gated SPECT MPI were categorized into minor hypoperfusion or major hypoperfusion groups. The major hypoperfusion group with 201Tl was divided into inferior or non-inferior wall hypoperfusion subgroups, and anteroseptal or non-anteroseptal wall hypoperfusion subgroups. Gated SPECT MPI data over a 360° acquisition orbit (360° images) and a 180° acquisition orbit (180° images) were reconstructed, and histogram bandwidth (HBW) and phase standard deviation (PSD) were compared.


Between 360° and 180° images with 201Tl, there were significant differences in HBW and PSD both globally (HBW 34.8 ± 16.6 vs. 29.1 ± 10.2; PSD 8.8 ± 4.9 vs. 7.0 ± 2.3, p < 0.05 for both) and in the inferior wall (HBW 29.5 ± 15.5 vs. 23.3 ± 9.0; PSD 7.6 ± 4.6 vs. 5.6 ± 2.4, p < 0.001 for both) in the major hypoperfusion group, and also in the inferior wall in all subgroups of the major hypoperfusion group. In contrast, no segment had any significant differences in HBW or PSD between 360° and 180° images with 99mTc.


Differences in acquisition orbit had a significant influence on HBW and PSD with 201Tl-gated SPECT MPI in the inferior wall in patients with major hypoperfusion myocardium.


Left ventricular mechanical dyssynchrony Gated SPECT myocardial perfusion imaging Phase analysis Acquisition orbit 


Compliance with ethical standards

Conflict of interest

The authors declare no conflict of interest associated with this manuscript.


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Copyright information

© The Japanese Society of Nuclear Medicine 2017

Authors and Affiliations

  • Tomofumi Misaka
    • 1
  • Makoto Hosono
    • 2
  • Takashi Kudo
    • 3
  • Takamichi Ito
    • 1
  • Tsutomu Syomura
    • 1
  • Masanobu Uemura
    • 1
  • Kaoru Okajima
    • 1
  1. 1.Department of RadiologyKindai University Nara HospitalNaraJapan
  2. 2.Faculty of Medicine, Institute of Advanced Clinical MedicineKindai UniversityOsaka-SayamaJapan
  3. 3.Department of Radioisotope Medicine, Atomic Bomb Disease InstituteNagasaki UniversityNagasakiJapan

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